Omega-3 fatty acids and mortality in patients referred for coronary angiography

• Verfasst von: Kleber, Marcus E. [VerfasserIn]
• Verfasst von: Delgado Gonzales de Kleber, Graciela [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Titel: Omega-3 fatty acids and mortality in patients referred for coronary angiography
• Titelzusatz: the Ludwigshafen Risk and Cardiovascular Health Study
• Verf.angabe: Marcus E. Kleber, Graciela E. Delgado, Stefan Lorkowski, Winfried März, Clemens von Schacky
• E-Jahr: 2016
• Jahr: September 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 25.02.2019 ; Available online 1 July 2016
• Titel Quelle: Enthalten in: Atherosclerosis
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1970
• Jahr Quelle: 2016
• Band/Heft Quelle: 252(2016), Seite 175-181
• ISSN Quelle: 1879-1484
• DOI: doi:10.1016/j.atherosclerosis.2016.06.049
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Alpha-linolenic acid
• Sach-SW: Docosahexaenoic acid
• Sach-SW: Eicosapentaenoic acid
• Sach-SW: Mortality
• Sach-SW: Omega-3 fatty acids
• K10plus-PPN: 1588011739

Abstract

Background and aims: There is an ongoing debate whether omega-3-fatty acids protect from cardiovascular disease mortality. We examined the associations of erythrocyte omega-3 fatty acids with mortality in patients referred for coronary angiography. Methods: Erythrocyte omega-3 fatty acid proportions were measured at baseline in 3259 participants of the Ludwigshafen Risk and Cardiovascular Health Study (LURIC) using the HS-Omega-3 Index method. Associations of omega-3 fatty acid proportions with mortality were investigated using Cox proportional hazards regression. Results: During a median follow-up of 9.9 years, 975 patients (29.9%) died, 614 patients (18.8%) from cardiovascular causes. Proportions of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were inversely associated with all-cause and cardiovascular mortality in models adjusted for conventional cardiovascular risk factors. The strongest association was observed for EPA with a hazard ratio (HR) of 0.89 (0.83-0.96) per increase of one standard deviation. Furthermore, we obtained evidence for a non-linear relation between EPA and mortality. Conclusions: EPA and DHA were associated with reduced mortality in LURIC, independent of other risk factors, with the association of EPA with mortality being non-linear.