Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

• Verfasst von: Demova, Hana [VerfasserIn]
• Verfasst von: Rose, Daniela [VerfasserIn]
• Verfasst von: Köppel, Hannes [VerfasserIn]
• Titel: Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy
• Verf.angabe: Hana Demova, Jana Boleckova, Daniela Rose, Hannes Koeppel, Bohumir Prochazka, Ludmila Brunerova, Ivan Rychlik, Marie Cerna
• E-Jahr: 2012
• Jahr: 10.02.2012
• Umfang: 10 S.
• Fussnoten: Gesehen am 27.02.2019
• Titel Quelle: Enthalten in: Central European journal of biology
• Ort Quelle: Warsaw : Central European Science Journals, 2006
• Jahr Quelle: 2012
• Band/Heft Quelle: 7(2012), 2, Seite 210-219
• ISSN Quelle: 1644-3632
• DOI: doi:10.2478/s11535-012-0003-x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1588163431

Abstract

Aconsiderablevariabilityintheincidenceandprevalenceofdiabeticnephropathy(DN)cohereswithanimportantcontributionofmultigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transpor ter 1 gene, the G/T (894) polymorphism and the T/C (-786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.