Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Demova, Hana [VerfasserIn]  |
| Rose, Daniela [VerfasserIn]  |
| Köppel, Hannes [VerfasserIn]  |
Titel: | Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy |
Verf.angabe: | Hana Demova, Jana Boleckova, Daniela Rose, Hannes Koeppel, Bohumir Prochazka, Ludmila Brunerova, Ivan Rychlik, Marie Cerna |
E-Jahr: | 2012 |
Jahr: | 10.02.2012 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 27.02.2019 |
Titel Quelle: | Enthalten in: Central European journal of biology |
Ort Quelle: | Warsaw : Central European Science Journals, 2006 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 7(2012), 2, Seite 210-219 |
ISSN Quelle: | 1644-3632 |
Abstract: | Aconsiderablevariabilityintheincidenceandprevalenceofdiabeticnephropathy(DN)cohereswithanimportantcontributionofmultigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transpor ter 1 gene, the G/T (894) polymorphism and the T/C (-786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes. |
DOI: | doi:10.2478/s11535-012-0003-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.2478/s11535-012-0003-x |
| Volltext: http://www.degruyter.com/view/j/biol.2012.7.issue-2/s11535-012-0003-x/s11535-012-0003-x.xml |
| DOI: https://doi.org/10.2478/s11535-012-0003-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1588163431 |
Verknüpfungen: | → Zeitschrift |
Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy / Demova, Hana [VerfasserIn]; 10.02.2012 (Online-Ressource)
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