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Verfasst von:Ronellenfitsch, Ulrich [VerfasserIn]   i
 Lippert, Christiane [VerfasserIn]   i
 Lang, Siegfried [VerfasserIn]   i
 Post, Stefan [VerfasserIn]   i
 Kähler, Georg [VerfasserIn]   i
 Gaiser, Timo [VerfasserIn]   i
Titel:Histology-based prediction of lymph node metastases in early gastric cancer as decision guidance for endoscopic resection
Verf.angabe:Ulrich Ronellenfitsch, Christiane Lippert, Rainer Grobholz, Siegfried Lang, Stefan Post, Georg Kähler and Timo Gaiser
E-Jahr:2016
Jahr:February 06, 2016
Umfang:8 S.
Fussnoten:Gesehen am 06.03.2019
Titel Quelle:Enthalten in: OncoTarget
Ort Quelle:[Erscheinungsort nicht ermittelbar] : Impact Journals LLC, 2010
Jahr Quelle:2016
Band/Heft Quelle:7(2016), 9, Seite 10676-10683
ISSN Quelle:1949-2553
Abstract:Background: Selected cases of early gastric cancer (EGC) can be successfully treated by endoscopic therapy if the risk of concurrent lymph node metastases (LNM) is negligible. Criteria for endoscopic resection based on risk factor analyses for LNM have been established mainly in Asia. However, it is not clear to what extent these recommendations can be transferred to Western collectives. The aim of this study was to analyze predictors for LNM in EGC in a Western study population. Methods: From our institutional archive, we selected all patients with gastric adenocarcinoma who had undergone gastrectomy with lymphadenectomy (1972 - 2005). Among 1970 patients 275 cases with EGC were identified. Clinical and pathological data were collected and logistic regression analyses performed. Results: LNM were present in 36/275 (13.1%) patients. With deeper invasion proportion of LNM increased. At submucosa level (sm1), patients were almost five times more likely to have LNM than at mucosa levels. Multivariable logistic regression analysis revealed lymphovascular invasion, diffuse- and mixed-type, and invasion depth as significant independent histopathological predictors of LNM. In patients with intestinal type according to Lauren and no lymphovascular invasion, we found only one LNM-positive case out of 43 patients in the pT1b (sm1 and sm2) groups. Conclusions: Our results underline the recommendation of most guidelines that endoscopic resection is sufficient for pT1a ECG because of the low incidence of LNM in this group. However, there seems also a role for endoscopic therapy in cases of pT1b (sm1/2) EGC with intestinal type differentiation and no lymphovascular invasion.
DOI:doi:10.18632/oncotarget.7221
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.18632/oncotarget.7221
 Volltext: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=7221&path[]=20619
 DOI: https://doi.org/10.18632/oncotarget.7221
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1588397726
Verknüpfungen:→ Zeitschrift

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