A level-set approach for a multi-scale cancer invasion model

• Verfasst von: Carraro, Thomas [VerfasserIn]
• Verfasst von: Wetterauer, Sven [VerfasserIn]
• Verfasst von: Ponce Bobadilla, Ana Victoria [VerfasserIn]
• Titel: A level-set approach for a multi-scale cancer invasion model
• Verf.angabe: Thomas Carraro, Sven E. Wetterauer, Ana Victoria Ponce Bobadilla, Dumitru Trucu
• E-Jahr: 2018
• Jahr: 19 May 2018
• Fussnoten: Gesehen am 11.03.2019
• Titel Quelle: Enthalten in: De.arxiv.org
• Ort Quelle: [S.l.] : Arxiv.org, 1991
• Jahr Quelle: 2018
• Band/Heft Quelle: (2018) Artikel-Nummer 1805.07485, 36 Seiten
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1588535436

Abstract

Central to the quest for a deeper understanding of the cancer growth and spread process, the naturally multiscale character of cancer invasion demands appropriate multiscale modelling and analysis approach. The cross-talk between the tissue scale (macro-scale) cancer cell population dynamics and the cell-scale (micro-scale) proteolytic molecular processes along the tumour boundary plays a particularly important role within the invasion processes, leading to dramatic changes in tumour morphology and influencing the overall pattern of cancer spread. Building on the multiscale moving boundary framework proposed in Trucu et al. (Multiscale Model. Simul 11(1): 309-335), in this work we propose a new formulation of this process involving a novel derivation of the macro-scale boundary movement law based on micro-dynamics, involving a transport equation combined with the level-set method. This is explored numerically in a novel finite element macro-micro framework based on cut-cells.