Status: Bibliographieeintrag
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| Verfasst von: | Rahm, Ann-Kathrin [VerfasserIn]  |
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| | Lugenbiel, Patrick [VerfasserIn] |
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| | Schweizer, Patrick Alexander [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Thomas, Dierk [VerfasserIn] |
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| Titel: | Role of ion channels in heart failure and channelopathies |
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| Verf.angabe: | Ann-Kathrin Rahm, Patrick Lugenbiel, Patrick A. Schweizer, Hugo A. Katus, Dierk Thomas |
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| E-Jahr: | 2018 |
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| Jahr: | 17 July 2018 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 27.03.2019 |
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| Titel Quelle: | Enthalten in: Biophysical reviews |
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| Ort Quelle: | Berlin : Springer, 2009 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 10(2018), 4, Seite 1097-1106 |
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| ISSN Quelle: | 1867-2469 |
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| Abstract: | Heart failure (HF) is a complication of multiple cardiac diseases and is characterized by impaired contractile and electric function. Patients with HF are not only limited by reduced contractile function but are also prone to life-threatening ventricular arrhythmias. HF itself leads to remodeling of ion channels, gap junctions, and intracellular calcium handling abnormalities that in combination with structural remodeling, e.g., fibrosis, produce a substrate for an arrhythmogenic disorders. Not only ventricular life-threatening arrhythmias contribute to increased morbidity and mortality but also atrial arrhythmias, especially atrial fibrillation (AF), are common in HF patients and contribute to morbidity and mortality. The distinct ion channel remodeling processes in HF and in channelopathies associated with HF will be discussed. Further basic research and clinical studies are needed to identify underlying molecular pathways of HF pathophysiology to provide the basis for improved patient care and individualized therapy based on individualized ion channel composition and remodeling. |
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| DOI: | doi:10.1007/s12551-018-0442-3 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s12551-018-0442-3 |
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| | DOI: https://doi.org/10.1007/s12551-018-0442-3 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Arrhythmia |
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| | Channelopathy |
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| | Heart failure |
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| | Ion channel |
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| | Pathophysiology |
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| K10plus-PPN: | 1662463901 |
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| Verknüpfungen: | → Zeitschrift |
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Role of ion channels in heart failure and channelopathies / Rahm, Ann-Kathrin [VerfasserIn]; 17 July 2018 (Online-Ressource)
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