| |  Online-Ressource |
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| Verfasst von: | Widera, Christian [VerfasserIn]  |
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| | Giannitsis, Evangelos [VerfasserIn] |
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| | Müller-Hennessen, Matthias [VerfasserIn] |
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| | Reimann, Ines [VerfasserIn] |
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| | Guba-Quint, Anja [VerfasserIn] |
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| | Marquardt, Ivonne [VerfasserIn] |
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| | Bethmann, Kerstin [VerfasserIn] |
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| | Meyer, Sven [VerfasserIn] |
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| Titel: | Diagnostic and prognostic value of sex- and age-specific cutpoints for high-sensitivity Troponin T in non-ST-elevation acute coronary syndrome |
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| Verf.angabe: | Christian Widera, Evangelos Giannitsis, Matthias Mueller-Hennessen, Ines Reimann, Anja Guba-Quint, Ivonne Marquardt, Kerstin Bethmann, Sven Meyer |
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| Jahr: | 2019 |
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| Jahr des Originals: | 2018 |
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| Umfang: | 7 S. |
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| Teil: | volume:275 |
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| | year:2019 |
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| | pages:13-19 |
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| | extent:7 |
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| Fussnoten: | Available online 11 October 2018 ; Gesehen am 09.05.2019 |
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| Titel Quelle: | Enthalten in: International journal of cardiology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1981 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 275(2019), Seite 13-19 |
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| ISSN Quelle: | 1874-1754 |
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| Abstract: | Introduction - Sex- and age-specific high-sensitivity Troponin T (hs-cTnT) cutpoints for the diagnosis and prognosis in acute coronary syndromes are not well established. We evaluated the use of such dichotomous thresholds for calculation of the GRACE score. - Methods - We analyzed a retrospective cohort study of 1146 patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Sex-dependent hs-cTnT cutpoints comprised 15.5ng/L for men and 9.0ng/L for women, while the sex-/age-specific cutpoints comprised 17ng/L for 50-64-year-old men and ≥65-year-old women, 31ng/L for ≥65-year-old men and 14ng/L for the remainder of patients. - Results - For the diagnosis of NSTEMI using sex-specific hs-cTnT cutpoints, in women, the positive likelihood ratio (LR+) was 2.04 (1.68-2.47) while in men, the negative likelihood ratio (LR−) was 0.05 (0.04-0.07). Using sex-/age-specific hs-cTnT cutpoints, in ≥65-year-old women the LR− was 0.09 (0.06-0.15), in 50 to 64-year-old men the LR− was 0.08 (0.04-0.13) while in ≥65-year-old men the LR− was 0.32 (0.28-0.37). Sex-specific hs-cTnT cutpoints achieved an NRI of −0.020 (95% CI, −0.101-0.118) for women and 0.030 (95% CI, −0.013-0.079) for men, and the sex-/age-specific hs-cTnT cutpoints achieved an NRI of 0.061 (95% CI, −0.019-0.132) for women and 0.021 (95% CI, −0.062-0.108) for men, while net benefit and clinical utility were highest for women using the sex-/age-specific hs-cTnT cutpoints. - Conclusions - Sex-dependent hs-cTNT cutpoints imply increasing diagnostic sensitivity for women at the cost of specificity. Considering age for hs-cTNT cutoffs slightly improves risk reclassification, although the overall gain in terms of the clinical management appears negligible. |
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| DOI: | doi:10.1016/j.ijcard.2018.10.027 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ijcard.2018.10.027 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0167527318322484 |
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| | DOI: https://doi.org/10.1016/j.ijcard.2018.10.027 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ACS |
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| | Diagnosis |
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| | Prognosis |
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| | Sex difference |
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| | Troponin T |
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| K10plus-PPN: | 1662492529 |
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| Verknüpfungen: | → Zeitschrift |
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Diagnostic and prognostic value of sex- and age-specific cutpoints for high-sensitivity Troponin T in non-ST-elevation acute coronary syndrome / Widera, Christian [VerfasserIn]; 2019 (Online-Ressource)
