Attention-deficit/hyperactivity disorder remission is linked to better neurophysiological error detection and attention-vigilance processes

• Verfasst von: Michelini, Giorgia [VerfasserIn]
• Verfasst von: Brandeis, Daniel [VerfasserIn]
• Verfasst von: Banaschewski, Tobias [VerfasserIn]
• Titel: Attention-deficit/hyperactivity disorder remission is linked to better neurophysiological error detection and attention-vigilance processes
• Verf.angabe: Giorgia Michelini, Glenn L. Kitsune, Celeste H. M. Cheung, Daniel Brandeis, Tobias Banaschewski, Philip Asherson, Gráinne McLoughlin, and Jonna Kuntsi
• E-Jahr: 2016
• Jahr: December 15, 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 28.03.2019
• Titel Quelle: Enthalten in: Biological psychiatry
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1985
• Jahr Quelle: 2016
• Band/Heft Quelle: 80(2016), 12, Seite 923-932
• ISSN Quelle: 1873-2402
• DOI: doi:10.1016/j.biopsych.2016.06.021
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ADHD
• Sach-SW: Cognitive impairments
• Sach-SW: EEG
• Sach-SW: Event-related potentials
• Sach-SW: Persistence
• Sach-SW: Remission
• K10plus-PPN: 1662494009

Abstract

Background - The processes underlying persistence and remission of attention-deficit/hyperactivity disorder (ADHD) are poorly understood. We examined whether cognitive and neurophysiological impairments on a performance-monitoring task distinguish between ADHD persisters and remitters. - Methods - On average 6 years after initial assessment, 110 adolescents and young adults with childhood ADHD (87 persisters, 23 remitters) and 169 age-matched control participants were compared on cognitive-performance measures and event-related potentials of conflict monitoring (N2) and error processing (error-related negativity and positivity) from an arrow flanker task with low-conflict and high-conflict conditions. ADHD outcome was examined with parent-reported symptoms and functional impairment measures using a categorical (DSM-IV) and a dimensional approach. - Results - ADHD persisters were impaired compared with controls on all cognitive-performance and event-related potential measures (all p < .05). ADHD remitters differed from persisters and were indistinguishable from control participants on the number of congruent (low-conflict) errors, reaction time variability, error-related negativity, and error-related positivity (all p ≤ .05). Remitters did not differ significantly from the other groups on incongruent (high-conflict) errors, mean reaction time, and N2. In dimensional analyses on all participants with childhood ADHD, ADHD symptoms and functional impairment at follow-up were significantly correlated with congruent errors, reaction time variability, and error-related positivity (r = .19-.23, p ≤ .05). - Conclusions - Cognitive and neurophysiological measures of attention-vigilance and error detection distinguished ADHD remitters from persisters. These results extend our previous findings with other tasks and indicate that such measures are markers of remission and candidates for the development of nonpharmacological interventions.