Emerging insights into the molecular and cellular basis of glioblastoma

• Verfasst von: Dunn, Gavin P. [VerfasserIn]
• Verfasst von: Campos, Benito [VerfasserIn]
• Titel: Emerging insights into the molecular and cellular basis of glioblastoma
• Verf.angabe: Gavin P. Dunn, Mikael L. Rinne, Jill Wykosky, Giannicola Genovese, Steven N. Quayle, Ian F. Dunn, Pankaj K. Agarwalla, Milan G. Chheda, Benito Campos, Alan Wang, Cameron Brennan, Keith L. Ligon, Frank Furnari, Webster K. Cavenee, Ronald A. Depinho, Lynda Chin, and William C. Hahn
• Jahr: 2012
• Umfang: 29 S.
• Fussnoten: Gesehen am 28.03.2019
• Titel Quelle: Enthalten in: Genes & development
• Ort Quelle: Stanford, Calif. : HighWire Press, 1987
• Jahr Quelle: 2012
• Band/Heft Quelle: 26(2012), 8, Seite 756-784
• ISSN Quelle: 1549-5477
• DOI: doi:10.1101/gad.187922.112
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: angiogenesis
• Sach-SW: glioblastoma
• Sach-SW: glioma classification
• Sach-SW: IDH1
• Sach-SW: invasion
• Sach-SW: tumor-initiating cells
• K10plus-PPN: 1662498551

Abstract

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that “glioblastoma” represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.