| |  Online-Ressource |
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| Verfasst von: | Gergei, Ingrid [VerfasserIn]  |
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| | Krämer, Bernhard [VerfasserIn] |
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| | März, Winfried [VerfasserIn] |
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| Titel: | Renal function, N-terminal Pro-B-type natriuretic peptide, propeptide big-endothelin and patients with heart failure and preserved ejection fraction |
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| Verf.angabe: | Ingrid Gergei, Bernhard K. Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März |
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| Jahr: | 2019 |
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| Jahr des Originals: | 2018 |
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| Umfang: | 6 S. |
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| Fussnoten: | Available online 21 April 2018 ; Gesehen am 29.03.2019 |
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| Titel Quelle: | Enthalten in: Peptides |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 111(2019), Seite 112-117 |
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| ISSN Quelle: | 1873-5169 |
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| Abstract: | Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. In general practice, where echocardiography is not readily available, a biomarker for the diagnosis of a heart failure with preserved ejection fraction (HFpEF) would be useful. Since cardiac diseases frequently coincide with renal disease, there is a high need of valid risk stratification methods in patients affected with both. We therefore examined NT-proBNP and another biomarker, Big-Endothelin-1, as a marker of HFpEF in patients with CKD. NT-proBNP and Big-ET-1 were determined in 439 patients with HFpEF in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. NT-proBNP plasma level has shown an exponential increase with declining GFR, while Big-ET-1 plasma level increased only in a moderate and linear fashion. In patients without CKD, a NT-proBNP cut-off point at 250pg/mL was suitable for the discrimination between HFpEF and patients without HF. When the GFR was less than 60mL/min/1.73m2, the NT-proBNP cut-off point should be raised to 750pg/mL. At a cutoff point at 0.85 fmol/L, Big-ET-1 allowed to distinguish patients with HFpEF from persons without HF, independently of GFR. In general, NT-proBNP is a good indicator of suspected heart failure. While for NT-proBNP different cut-off points have to be considered in the diagnosis of HFpEF, a single cut-off point of Big-ET-1 was appropriate in the diagnosis of HFpEF, regardless of the presence or absence of CKD. An additional measurement of Big-ET-1 improves the diagnosis of HFpEF in patients with chronic kidney disease. |
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| DOI: | doi:10.1016/j.peptides.2018.04.003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.peptides.2018.04.003 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0196978118300718 |
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| | DOI: https://doi.org/10.1016/j.peptides.2018.04.003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Big-Endothelin-1 (Big-ET-1) |
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| | Biomarkers |
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| | Chronic kidney disease (CKD) |
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| | Heart failure with preserved ejection fraction (HFpEF) |
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| | N-Terminal Pro-B-Type natriuretic peptide (NT-proBNP) |
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| | Peptides |
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| K10plus-PPN: | 1662530560 |
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| Verknüpfungen: | → Zeitschrift |
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Renal function, N-terminal Pro-B-type natriuretic peptide, propeptide big-endothelin and patients with heart failure and preserved ejection fraction / Gergei, Ingrid [VerfasserIn]; 2019 (Online-Ressource)
