Aberrant cortical neurodevelopment in major depressive disorder

• Verfasst von: Schmitgen, Mike [VerfasserIn]
• Verfasst von: Depping, Malte S. [VerfasserIn]
• Verfasst von: Bach, Claudia [VerfasserIn]
• Verfasst von: Wolf, Nadine D. [VerfasserIn]
• Verfasst von: Kubera, Katharina Maria [VerfasserIn]
• Verfasst von: Hirjak, Dusan [VerfasserIn]
• Verfasst von: Wolf, Robert Christian [VerfasserIn]
• Titel: Aberrant cortical neurodevelopment in major depressive disorder
• Verf.angabe: Mike M. Schmitgen, Malte S. Depping, Claudia Bach, Nadine D. Wolf, Katharina M. Kubera, Nenad Vasic, Dusan Hirjak, Fabio Sambataro, Robert C. Wolf
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 8 S.
• Fussnoten: Available online 11 September 2018 ; Gesehen am 29.03.2019
• Titel Quelle: Enthalten in: Journal of affective disorders
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1979
• Jahr Quelle: 2019
• Band/Heft Quelle: 243(2019), Seite 340-347
• ISSN Quelle: 1573-2517
• DOI: doi:10.1016/j.jad.2018.09.021
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cortex
• Sach-SW: Cortical thickness
• Sach-SW: Depression
• Sach-SW: Gyrification
• Sach-SW: MRI
• Sach-SW: Vulnerability
• K10plus-PPN: 1662531672

Abstract

Background - There is strong neuroimaging evidence that cortical alterations represent a core pathophysiological feature of major depressive disorder (MDD). Differential contributions of cortical features of neurodevelopmental origin, which may distinctly contribute to MDD vulnerability, disease-onset, or symptom expression, are unclear at present. - Methods - We investigated distinct markers of cortical neurodevelopment, i.e. local cortical gyrification (LGI) and thickness (CT) in patients with MDD (n=38) and healthy controls (HC, n=22) using 3 T structural magnetic resonance imaging data and surface-based data analysis techniques. CT and LGI were computed using the Computational Anatomy Toolbox (CAT12). Analyses were performed for the entire cortical surface followed by a complementary regions-of-interest approach. - Results - MDD patients showed significantly greater LGI in frontal, cingulate, parietal, temporal, and occipital regions compared to HC (FDR-corrected at p<0.05 using threshold-free cluster enhancement). No significant differences of CT were found. In the MDD-group, correlations were found between duration of illness in years and number of depressive episodes and LGI of frontal, temporal, and parietal regions (p<0.05). - Limitations - Main limitations are the relatively modest sample size and a cross-sectional study design. We did not control for early environmental factors potentially influencing neurodevelopment, such as childhood trauma. We report associations uncorrected for multiple comparisons. - Conclusions - The data suggest different local trajectories of cortical change in MDD. In addition, our data support the notion that aberrant cortical development may serve as a vulnerability marker of MDD, as well as a potential predictor of disease course.