Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis

• Verfasst von: Eisele, Philipp [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Verfasst von: Ebert, Anne [VerfasserIn]
• Verfasst von: Radbruch, Alexander [VerfasserIn]
• Verfasst von: Platten, Michael [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Titel: Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis
• Verf.angabe: Philipp Eisele, Kristina Szabo, Anne Ebert, Alexander Radbruch, Michael Platten, Stefan O. Schoenberg, Achim Gass
• E-Jahr: 2019
• Jahr: 29.03.2019
• Umfang: 5 S.
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 2019
• Band/Heft Quelle: 58(2019), Seite 1-5
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/j.mri.2019.01.007
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: ADC
• Sach-SW: Dentate nucleus
• Sach-SW: Diffusion
• Sach-SW: Gadolinium
• Sach-SW: MRI
• K10plus-PPN: 166253194X

Abstract

Objective - Over the last years several studies reported an increased signal intensity (SI) of the dentate nucleus (DN) on unenhanced T1-weighted images after repeated application of gadolinium-based contrast agents (GBCAs), suggesting gadolinium deposition. The aim of this study was to investigate with diffusion-weighted MRI possible tissue abnormalities of the DN in multiple sclerosis (MS) patients. - Material and methods - We retrospectively identified seventeen patients with at least six contrast-enhanced MRI examinations by using the linear GBCA gadopentate dimeglumine and twenty-three patients with the exclusive use of the macrocyclic contrast agent gadoterate meglumine followed by another 3 Tesla MRI scan including unenhanced T1-weighted and diffusion-weighted images. - Results - In the linear GBCA group, we found significant differences of the DN-to-pons SI ratio on unenhanced T1-weighted images (1.13±0.05) when compared to the macrocyclic GBCA group (0.97±0.03; p<0.001). However, we found no significant differences between apparent diffusion coefficient (ADC) values of the DN in both groups (linear GBCA group: 0.82±0.04×10−3mm/s2; marcocyclic GBCA group: 0.79±0.04×10−3mm/s2; p=0.15). - Conclusions - Our results do not suggest that there is any difference in ADC values in the T1-hyperintense DN, which does not indicate a difference in tissue integrity between patients exposed to macrocyclic or linear GBCAs.