Pleiotropic effect of lipoprotein-apheresis on the soluble form of activated leukocyte cell adhesion molecule (sALCAM) in familial hypercholesterolaemia

• Verfasst von: Bauer, Rüdiger von [VerfasserIn]
• Verfasst von: Oikonomou, Dimitrios [VerfasserIn]
• Verfasst von: Sulaj, Alba [VerfasserIn]
• Verfasst von: Kopf, Stefan [VerfasserIn]
• Verfasst von: Fleming, Thomas [VerfasserIn]
• Verfasst von: Nawroth, Peter Paul [VerfasserIn]
• Titel: Pleiotropic effect of lipoprotein-apheresis on the soluble form of activated leukocyte cell adhesion molecule (sALCAM) in familial hypercholesterolaemia
• Verf.angabe: Rüdiger von Bauer, Dimitrios Oikonomou, Alba Sulaj, Stefan Kopf, Thomas Fleming, Gottfried Rudofsky, Peter Nawroth
• E-Jahr: 2018
• Jahr: June 11, 2018
• Umfang: 5 S.
• Fussnoten: Gesehen am 01.04.2019 ; Epub ahead of print
• Titel Quelle: Enthalten in: Experimental and clinical endocrinology & diabetes
• Ort Quelle: Stuttgart [u.a.] : Thieme, 1983
• Jahr Quelle: 2018
• Band/Heft Quelle: 126(2018), Seite 1-5
• ISSN Quelle: 1439-3646
• DOI: doi:10.1055/a-0630-0232
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1662614187

Abstract

Introduction/Background: Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation.