Prevention of carcinogenesis and metastasis by artemisinin-type drugs

• Verfasst von: Abba, Mohammed L. [VerfasserIn]
• Verfasst von: Patil, Nitin [VerfasserIn]
• Verfasst von: Leupold, Jörg [VerfasserIn]
• Verfasst von: Allgayer, Heike [VerfasserIn]
• Titel: Prevention of carcinogenesis and metastasis by artemisinin-type drugs
• Verf.angabe: Mohammed L. Abba, Nitin Patil, Jörg Hendrik Leupold, Mohamed E.M. Saeed, Thomas Efferth, Heike Allgayer
• E-Jahr: 2018
• Jahr: 8 May 2018
• Umfang: 8 S.
• Fussnoten: Gesehen am 02.04.2019
• Titel Quelle: Enthalten in: Cancer letters
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2018
• Band/Heft Quelle: 429(2018), Seite 11-18
• ISSN Quelle: 1872-7980
• DOI: doi:10.1016/j.canlet.2018.05.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cancer
• Sach-SW: Carcinogenesis
• Sach-SW: Initation
• Sach-SW: L.
• Sach-SW: Metastasis
• Sach-SW: Prevention
• Sach-SW: Progression
• K10plus-PPN: 166270271X

Abstract

Artemisia annua (sweet wormwood, qinhao) is an ancient Chinese herbal remedy for pyrexia. Nowadays, artemisinin (qinghaosu) and its derivatives belong to the standard therapies against malaria worldwide, and its discovery has led to the Nobel Prize in Physiology and Medicine to Youyou Tu in 2015. While most attention has been paid to the treatment of malaria, there is increasing evidence that Artemisinin-type drugs bear a considerable potential to treat and prevent cancer. Rather than reporting on therapy of cancer, this review gives a comprehensive and timely overview on the chemopreventive effects of artemisinin and its derivatives against carcinogenesis and metastasis formation, following the multistage model of carcinogenesis (initiation, promotion, progression). The favorable toxicity profile known from malaria studies indicates that artemisinin-type drugs may be safely applied to prevent carcinogenesis and cancer metastasis in human beings.