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Verfasst von:Wortmann, Markus [VerfasserIn]   i
 Xiao, Xianghui [VerfasserIn]   i
 Wabnitz, Guido H. [VerfasserIn]   i
 Samstag, Yvonne [VerfasserIn]   i
 Hakimi, Maani [VerfasserIn]   i
 Böckler, Dittmar [VerfasserIn]   i
 Dihlmann, Susanne [VerfasserIn]   i
Titel:AIM2 levels and DNA-triggered inflammasome response are increased in peripheral leukocytes of patients with abdominal aortic aneurysm
Verf.angabe:Markus Wortmann, Xianghui Xiao, Guido Wabnitz, Yvonne Samstag, Maani Hakimi, Dittmar Böckler, Susanne Dihlmann
E-Jahr:2019
Jahr:13 February 2019
Umfang:9 S.
Fussnoten:Gesehen am 03.04.2019
Titel Quelle:Enthalten in: Inflammation research
Ort Quelle:Cham : Springer International Publishing AG, 1969
Jahr Quelle:2019
Band/Heft Quelle:68(2019), 4, Seite 337-345
ISSN Quelle:1420-908X
Abstract:Objective and designAbdominal aortic aneurysm (AAA) is heavily infiltrated with leukocytes, expressing the DNA sensor absent in melanoma 2 (AIM2) and other inflammasome components.MethodsUsing multicolour flow cytometry, we here compared the expression of the inflammasome components AIM2, NLRP3, and ASC in different peripheral immune cells derived from AAA patients with those from non-AAA patients in a case-control study. In parallel, peripheral blood mononuclear cells (PBMC) of AAA patients and controls were stimulated in vitro with poly-dA:dT or lipopolysaccharide (LPS) to analyze inflammasome activation.ResultsAIM2 expression was significantly increased in peripheral granulocytes (P = 0.026), monocytes (P = 0.007), B lymphocytes (P < 0.0001), and T lymphocytes (P = 0.004) of AAA patients. Expression of other inflammasome components did not differ between the groups. Following in vitro stimulation with foreign DNA, PBMC derived from AAA patients released significantly more IL-1β (P = 0.022) into the supernatant than PBMC from control patients. In contrast, IL-1β release upon LPS stimulation did not differ between the PBMC groups.ConclusionThe data indicate the increased activation of an AIM2 inflammasome in peripheral immune cells of AAA patients and point to a systemic AIM2-associated immune response to AAA.
DOI:doi:10.1007/s00011-019-01212-4
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00011-019-01212-4
 DOI: https://doi.org/10.1007/s00011-019-01212-4
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Abdominal aortic aneurysm
 FACS
 Flow cytometry
 Inflammasome
 Innate immunity
 PBMC
K10plus-PPN:1662755783
Verknüpfungen:→ Zeitschrift

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