Membrane-associated RNA-binding proteins orchestrate organelle-coupled translation

• Verfasst von: Béthune, Julien [VerfasserIn]
• Titel: Membrane-associated RNA-binding proteins orchestrate organelle-coupled translation
• Verf.angabe: Julien Béthune, Ralf-Peter Jansen, Michael Feldbrügge, and Kathi Zarnack
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 11 S.
• Fussnoten: Available online 16 November 2018 ; Gesehen am 03.04.2019
• Titel Quelle: Enthalten in: Trends in cell biology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1991
• Jahr Quelle: 2019
• Band/Heft Quelle: 29(2019), 2, Seite 178-188
• ISSN Quelle: 1879-3088
• DOI: doi:10.1016/j.tcb.2018.10.005
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: 3′ untranslated region
• Sach-SW: endoplasmic reticulum
• Sach-SW: endosomes
• Sach-SW: local translation
• Sach-SW: mitochondria
• Sach-SW: organelle
• K10plus-PPN: 1662781911

Abstract

Proteins are positioned and act at defined subcellular locations. This is particularly important in eukaryotic cells that deliver proteins to membrane-bound organelles such as the endoplasmic reticulum (ER), mitochondria, or endosomes. It is axiomatic that organelle targeting depends mainly on polypeptide signals. However, recent results demonstrate that targeting elements within the encoding transcripts are essential for efficient protein localisation. Key readers of these elements are membrane-associated RNA-binding proteins (memRBPs) that orchestrate organelle-coupled translation. The translation products then either cross the membrane for organelle entry or hitchhike on organelle surfaces for complex assembly and co-transport. Understanding the interaction of protein- and RNA-based targeting signals is essential to decipher the molecular basis for mutant phenotypes in disease.