Frequency and temporal profile of recanalization after cerebral vein and sinus thrombosis

• Verfasst von: Herweh, Christian [VerfasserIn]
• Verfasst von: Griebe, Martin [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Verfasst von: Neumaier-Probst, Eva [VerfasserIn]
• Verfasst von: Hennerici, Michael G. [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Ringleb, Peter A. [VerfasserIn]
• Verfasst von: Nagel, Simon [VerfasserIn]
• Titel: Frequency and temporal profile of recanalization after cerebral vein and sinus thrombosis
• Verf.angabe: C. Herweh, M. Griebe, C. Geisbüsch, K. Szabo, E. Neumaier‐Probst, M.G. Hennerici, M. Bendszus, P.A. Ringleb and S. Nagel
• Jahr: 2016
• Umfang: 7 S.
• Fussnoten: Gesehen am 04.04.2019 ; First published: 19 November 2015
• Titel Quelle: Enthalten in: European journal of neurology
• Ort Quelle: Oxford [u.a.] : Wiley-Blackwell, 1994
• Jahr Quelle: 2016
• Band/Heft Quelle: 23(2016), 4, Seite 681-687
• ISSN Quelle: 1468-1331
• DOI: doi:10.1111/ene.12901
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: anticoagulation
• Sach-SW: cerebral sinus and venous thrombosis
• Sach-SW: recanalization
• K10plus-PPN: 1662853548

Abstract

Background and purpose The temporal course of recanalization and its association with clinical outcome were analysed in our patients with cerebral sinus and/or venous thrombosis (CSVT) and follow-up magnetic resonance imaging (MRI). Methods Between January 1998 and September 2014 all patients from our institutions with CSVT were systematically analysed. Baseline data, treatment characteristics and follow-up MRI were retrospectively recorded. The status of recanalization was assessed as complete (CRec), partial (PRec) or failed recanalization. Clinical follow-up was measured with the modified Rankin Scale. Excellent outcome was defined as modified Rankin Scale 0-1. Results Ninety-nine patients were identified; 97% of these patients were treated with oral anticoagulation (OAC) and the median (min-max) time of OAC was 7 months (1-84). CRec was achieved in 57.6% (57/99), PRec in 29.3% (29/99) and only 13 (13.1%) patients did not recanalize. The median (min-max) time to PRec was 4 months (0.25-14) and to CRec 6 months (2-34). Median time to last clinical follow-up was 8 months (1-88); 91.8% (89/99) had an excellent outcome at last clinical follow-up and only 2.1% (2/99) died. Only thrombosis of the superior sagittal sinus was independently associated with successful recanalization (odds ratio 16, 95% confidence interval 2-138). No severe haemorrhagic complications and no recurrence of CSVT occurred within clinical follow-up. No association of outcome and recanalization status was found. Conclusions The recanalization rate of CSVT under OAC was high and the median time to CRec was 6 months. Thrombosis of the superior sagittal sinus is a positive predictor of recanalization. Outcome in this cohort was excellent but no significant association of outcome and recanalization status was found.