Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Vulser, Hélène [VerfasserIn]   i
 Struve, Maren [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Nees, Frauke [VerfasserIn]   i
Titel:Early variations in white matter microstructure and depression outcome in adolescents with subthreshold depression
Verf.angabe:Hélène Vulser, Marie-Laure Paillère Martinot, Eric Artiges, Ruben Miranda, Jani Penttilä, Yvonne Grimmer, Betteke M. van Noort, Argyris Stringaris, Maren Struve, Tahmine Fadai, Viola Kappel, Robert Goodman, Eleni Tzavara, Charbel Massaad, Tobias Banaschewski, Gareth J. Barker, Arun L. W. Bokde, Uli Bromberg, Rüdiger Brühl, Christian Büchel, Anna Cattrell, Patricia Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Juergen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Frauke Nees, Dimitri Papadopoulos-Orfanos, Tomas Paus, Luise Poustka, Sarah Rodehacke, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Jean-Luc Martinot, Hervé Lemaitre, IMAGEN Consortium
E-Jahr:2018
Jahr:16 August 2018
Umfang:10 S.
Fussnoten:Gesehen am 10.04.2019
Titel Quelle:Enthalten in: The American journal of psychiatry
Ort Quelle:Stanford, Calif. : HighWire Press, 1844
Jahr Quelle:2018
Band/Heft Quelle:175(2018), 12, Seite 1255-1264
ISSN Quelle:1535-7228
Abstract:OBJECTIVE:: White matter microstructure alterations have recently been associated with depressive episodes during adolescence, but it is unknown whether they predate depression. The authors investigated whether subthreshold depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. - METHOD:: Adolescents with subthreshold depression (N=96) and healthy control subjects (N=336) drawn from a community-based cohort were compared using diffusion tensor imaging and whole brain tract-based spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followed up at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines spreading from the regions identified in the TBSS analysis and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. The authors searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold depression and depression at follow-up, and then explored the specificity of the findings. - RESULTS:: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between subthreshold depression at baseline and depression at follow-up was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. - CONCLUSIONS:: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.
DOI:doi:10.1176/appi.ajp.2018.17070825
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1176/appi.ajp.2018.17070825
 DOI: https://doi.org/10.1176/appi.ajp.2018.17070825
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescents
 Brain Imaging Techniques
 Mood Disorders-Unipolar
 Neuroanatomy
 Outcome Studies
K10plus-PPN:1663076413
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68379650   QR-Code
zum Seitenanfang