| |  Online-Ressource |
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| Verfasst von: | Doll, Sophia [VerfasserIn]  |
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| | Kriegmair, Maximilian [VerfasserIn] |
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| | Porubský, Štefan [VerfasserIn] |
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| | Nuhn, Philipp [VerfasserIn] |
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| Titel: | Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient |
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| Verf.angabe: | Sophia Doll, Maximilian C. Kriegmair, Alberto Santos, Michael Wierer, Fabian Coscia, Helen Michele Neil, Stefan Porubsky, Philipp E. Geyer, Andreas Mund, Philipp Nuhn and Matthias Mann |
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| E-Jahr: | 2018 |
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| Jahr: | 14 June 2018 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 10.04.2019 |
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| Titel Quelle: | Enthalten in: Molecular oncology |
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| Ort Quelle: | Hoboken, NJ : John Wiley & Sons, Inc., 2007 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 12(2018), 8, Seite 1296-1307 |
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| ISSN Quelle: | 1878-0261 |
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| Abstract: | Recent advances in mass spectrometry (MS)-based technologies are now set to transform translational cancer proteomics from an idea to a practice. Here, we present a robust proteomic workflow for the analysis of clinically relevant human cancer tissues that allows quantitation of thousands of tumor proteins in several hours of measuring time and a total turnaround of a few days. We applied it to a chemorefractory metastatic case of the extremely rare urachal carcinoma. Quantitative comparison of lung metastases and surrounding tissue revealed several significantly upregulated proteins, among them lysine-specific histone demethylase 1 (LSD1/KDM1A). LSD1 is an epigenetic regulator and the target of active development efforts in oncology. Thus, clinical cancer proteomics can rapidly and efficiently identify actionable therapeutic options. While currently described for a single case study, we envision that it can be applied broadly to other patients in a similar condition. |
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| DOI: | doi:10.1002/1878-0261.12326 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/1878-0261.12326 |
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| | Volltext: https://febs.onlinelibrary.wiley.com/doi/abs/10.1002/1878-0261.12326 |
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| | DOI: https://doi.org/10.1002/1878-0261.12326 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | case study |
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| | clinical proteomics |
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| | epigenetics |
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| | mass spectrometry |
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| | urachal carcinoma |
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| K10plus-PPN: | 1663081689 |
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| Verknüpfungen: | → Zeitschrift |
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Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient / Doll, Sophia [VerfasserIn]; 14 June 2018 (Online-Ressource)
