Differential use of the C-type lectins L-SIGN and DC-SIGN for phlebovirus endocytosis

• Verfasst von: Léger, Psylvia [VerfasserIn]
• Verfasst von: Youness, Berthe [VerfasserIn]
• Verfasst von: Cordes, Nicole [VerfasserIn]
• Verfasst von: Lozach, Pierre-Yves [VerfasserIn]
• Titel: Differential use of the C-type lectins L-SIGN and DC-SIGN for phlebovirus endocytosis
• Verf.angabe: Psylvia Léger, Marilou Tetard, Berthe Youness, Nicole Cordes, Ronan N. Rouxel, Marie Flamand and Pierre-Yves Lozach
• E-Jahr: 2016
• Jahr: 2016 Apr 21
• Umfang: 18 S.
• Fussnoten: Gesehen am 10.04.2019
• Titel Quelle: Enthalten in: Traffic
• Ort Quelle: Oxford : Wiley-Blackwell, 2000
• Jahr Quelle: 2016
• Band/Heft Quelle: 17(2016), 6, Seite 639-656
• ISSN Quelle: 1600-0854
• DOI: doi:10.1111/tra.12393
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: binding
• Sach-SW: bunyavirus
• Sach-SW: C-type lectins
• Sach-SW: CD209
• Sach-SW: CD209L
• Sach-SW: DC-SIGN
• Sach-SW: DC-SIGNR
• Sach-SW: endocytic motif
• Sach-SW: endocytosis
• Sach-SW: L-SIGN
• Sach-SW: phlebovirus
• Sach-SW: Rift Valley fever virus
• Sach-SW: uptake
• Sach-SW: Uukuniemi virus
• Sach-SW: virus receptor
• K10plus-PPN: 166309389X

Abstract

The receptors and cellular factors used by phleboviruses (Bunyaviridae) to enter host cells remain largely unidentified. In addition to the C-type lectin DC-SIGN (Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin), we report here that several phleboviruses subvert the closely related protein L-SIGN for infection. Together, our results establish that L-SIGN is an attachment factor not required for virus internalization whereas DC-SIGN is an authentic entry receptor required for both binding and endocytosis. Our study underlines the importance of the subsequent entry processes in virus-receptor interactions beyond attachment.