Intraocular pressure elevation and choroidal thinning

• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Intraocular pressure elevation and choroidal thinning
• Verf.angabe: Ya Xing Wang, Ran Jiang, Xiao Lei Ren, Jian Dong Chen, Hong Li Shi, Liang Xu, Wen Bin Wei, Jost B. Jonas
• E-Jahr: 2016
• Jahr: 25 March 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 11.04.2019
• Titel Quelle: Enthalten in: British journal of ophthalmology
• Ort Quelle: London : BMJ Publ. Group, 1917
• Jahr Quelle: 2016
• Band/Heft Quelle: 100(2016), 12, Seite 1676-1681
• ISSN Quelle: 1468-2079
• DOI: doi:10.1136/bjophthalmol-2015-308062
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Choroid
• Sach-SW: Glaucoma
• Sach-SW: Imaging
• Sach-SW: Intraocular pressure
• K10plus-PPN: 166313331X

Abstract

Purpose To evaluate changes in subfoveal choroidal thickness (SFCT) and peripapillary choroidal thickness (PPCT) after acute intraocular pressure (IOP) elevation provoked by a dark room prone provocative test (DRPPT). - Methods The prospective cohort study included 114 eyes from 65 individuals who had an IOP elevation ≥2 mm Hg during the DRPPT. The participants stayed in a dark room for 2 h with the forehead placed on a desk. At baseline and within 5 min after the end of the DRPPT, tonometry and enhanced depth imaging by spectral-domain optical coherence tomography were carried out. - Results During the DRPPT, IOP increased by 10.1±10.9 mm Hg, SFCT decreased significantly (p<0.001) from 280±80 µm to 267±76 µm and PPCT decreased significantly (p<0.001) from 177±74 to 169±70 µm. In multivariate analysis, a more marked SFCT thinning was associated with higher IOP increase (p<0.001) and shallower anterior chamber depth at baseline (p=0.01). In a similar manner, a higher PPCT change was correlated with a higher IOP increase (p<0.001), and a thicker choroidal thickness at baseline (p<0.001). - Conclusions Choroidal thickness in the subfoveal region and in the peripapillary region decreased parallel to an acute increase in IOP in individuals 2 h after a dark room test. Choroidal thickness depends on the actual IOP, which may be noted when choroidal thickness is measured.