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Verfasst von:Lammert, Alexander [VerfasserIn]   i
 Nittka, Stefanie [VerfasserIn]   i
 Otto, Mirko [VerfasserIn]   i
 Schneider-Lindner, Verena [VerfasserIn]   i
 Krämer, Bernhard [VerfasserIn]   i
 Birck, Rainer [VerfasserIn]   i
 Hammes, Hans-Peter [VerfasserIn]   i
 Benck, Urs Tobias [VerfasserIn]   i
Titel:Performance of the 1 mg dexamethasone suppression test in patients with severe obesity
Verf.angabe:Alexander Lammert, Stefanie Nittka, Mirko Otto, Verena Schneider‐Lindner, Anne Kemmer, Bernhard K. Krämer, Rainer Birck, Hans-Peter Hammes, and Urs Benck
E-Jahr:2016
Jahr:7 March 2016
Umfang:6 S.
Fussnoten:Gesehen am 11.04.2019
Titel Quelle:Enthalten in: Obesity
Ort Quelle:Hoboken, NJ : Wiley, 1993
Jahr Quelle:2016
Band/Heft Quelle:24(2016), 4, Seite 850-855
ISSN Quelle:1930-739X
Abstract:Objective To analyze the performance of the 1 mg dexamethasone suppression test (DST) in patients with obesity. Special attention was paid to the influence of interfering medication on DST. Methods In this prospective cohort study (Mannheim Obesity Study), patients with obesity were evaluated before bariatric surgery. For evaluation of hypercortisolism, a 1 mg dexamethasone-suppression test (DST) in all subjects was performed. Medication was assessed for possible interference. Results Two hundred seventy-eight patients with a mean age of 42.3 years (68.8% women) and a mean BMI of 47.9 ± 8.4 kg/m2 were screened. Insufficient suppression of cortisol after DST was found in 24 patients (8.6%). In two patients hypercortisolism was confirmed. The specificity for DST was calculated at 92.0%. Only CYP3A4 inducers (n = 22, 7.9%) and estrogen therapy (n = 17, 6.1%) were significantly associated with falsely elevated cortisol after DST. Regression analysis excluded any interrelation between DST and anthropometry. Conclusions Low prevalence of hypercortisolism (0.7 or <1.8%) was found. Specificity of DST in this cohort typically screened for hypercortisolism was 92.0% (≤ 50 nmol/L). DST should be avoided in patients taking CYP3A4 inducers or estrogen therapy, due to their significant interaction. In summary, the 1 mg DST is an adequate test for screening for hypercortisolism even in patients with extreme obesity.
DOI:doi:10.1002/oby.21442
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1002/oby.21442
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/oby.21442
 DOI: https://doi.org/10.1002/oby.21442
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:166313801X
Verknüpfungen:→ Zeitschrift

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