Differential resting-state connectivity patterns of the right anterior and posterior dorsolateral prefrontal cortices (DLPFC) in schizophrenia

• Verfasst von: Chechko, Natalya [VerfasserIn]
• Verfasst von: Gruber, Oliver [VerfasserIn]
• Titel: Differential resting-state connectivity patterns of the right anterior and posterior dorsolateral prefrontal cortices (DLPFC) in schizophrenia
• Verf.angabe: Natalia Chechko, Edna C. Cieslik, Veronika I. Müller, Thomas Nickl-Jockschat, Birgit Derntl, Lydia Kogler, André Aleman, Renaud Jardri, Iris E. Sommer, Oliver Gruber, Simon B. Eickhoff
• E-Jahr: 2018
• Jahr: 28 May 2018
• Umfang: 13 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.04.2019
• Titel Quelle: Enthalten in: Frontiers in psychiatry
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2018
• Band/Heft Quelle: 9(2018), Artikel-ID 211
• ISSN Quelle: 1664-0640
• DOI: doi:10.3389/fpsyt.2018.00211
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: DLPFC
• Sach-SW: fMRI neuroimaging
• Sach-SW: parcellation
• Sach-SW: Resting-state fMRI
• Sach-SW: Schizophrenia
• K10plus-PPN: 1663201102

Abstract

In schizophrenia (SCZ), dysfunction of the dorsolateral prefrontal cortex (DLPFC) has been linked to the deficits in executive functions and attention. It has been suggested that, instead of considering the right DLPFC as a cohesive functional entity, it can be divided into two parts (anterior and posterior) based on its whole-brain connectivity patterns. Given these two subregions' differential association with cognitive processes, we investigated the functional connectivity (FC) profile of both subregions through resting-state data to determine whether they are differentially affected in SCZ. Resting-state magnetic resonance imaging (MRI) scans were obtained from 120 patients and 172 healthy controls (HC) at 6 different MRI sites. The results showed differential FC patterns for the anterior and posterior parts of the right executive control- related DLPFC in SCZ with the parietal, the temporal and the cerebellar regions, along with a convergent reduction of connectivity with the striatum and the occipital cortex. An increased psychopathology level was linked to a higher difference in posterior versus anterior FC for the left IFG/anterior insula, regions involved in higher-order cognitive processes. In sum, the current analysis demonstrated that even between two neighbouring clusters connectivity could be differentially disrupted in SCZ. Lacking the necessary anatomical specificity, such notions may in fact be detrimental to a proper understanding of SCZ pathophysiology.