| Online-Ressource |
Verfasst von: | Wagener, Rabea [VerfasserIn]  |
| Raimondi, Francesco [VerfasserIn]  |
| Kleinheinz, Kortine [VerfasserIn]  |
| Hübschmann, Daniel [VerfasserIn]  |
| Russell, Robert B. [VerfasserIn]  |
Titel: | The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma |
Verf.angabe: | Rabea Wagener, Julian Seufert, Francesco Raimondi, Susanne Bens, Kortine Kleinheinz, Inga Nagel, Janine Altmüller, Holger Thiele, Daniel Hübschmann, Christian W. Kohler, Peter Nürnberg, Rex Au-Yeung, Birgit Burkhardt, Heike Horn, Lorenzo Leoncini, Elaine S. Jaffe, German Ott, Grzegorz Rymkiewicz, Matthias Schlesner, Robert B. Russell, Wolfram Klapper, and Reiner Siebert |
Jahr: | 2019 |
Jahr des Originals: | 2018 |
Umfang: | 5 S. |
Fussnoten: | Prepublished online as Blood First Edition paper, 19 December 2018 ; Gesehen am 15.04.2019 |
Titel Quelle: | Enthalten in: Blood |
Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 133(2019), 9, Seite 962-966 |
ISSN Quelle: | 1528-0020 |
Abstract: | The new recently described provisional lymphoma category Burkitt-like lymphoma with 11q aberration comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene-expression levels but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy-number analysis and whole-exome sequencing. We refined the regions of 11q imbalance and identified the INO80 complex-associated gene NFRKB as a positional candidate in 11q24.3. Next to recurrent gains in 12q13.11-q24.32 and 7q34-qter as well as losses in 13q32.3-q34, we identified 47 genes recurrently affected by protein-changing mutations (each ≥3 of 15 cases). Strikingly, we did not detect recurrent mutations in genes of the ID3-TCF3 axis or the SWI/SNF complex that are frequently altered in BL, or in genes frequently mutated in germinal center-derived B-cell lymphomas like KMT2D or CREBBP An exception is GNA13, which was mutated in 7 of 15 cases. We conclude that the genomic landscape of mnBLL,11q, differs from that of BL both at the chromosomal and mutational levels. Our findings implicate that mnBLL,11q, is a lymphoma category distinct from BL at the molecular level. |
DOI: | doi:10.1182/blood-2018-07-864025 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1182/blood-2018-07-864025 |
| DOI: https://doi.org/10.1182/blood-2018-07-864025 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1663249164 |
Verknüpfungen: | → Zeitschrift |
¬The¬ mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma / Wagener, Rabea [VerfasserIn]; 2019 (Online-Ressource)