Alpha-synuclein’s degradation in vivo

• Verfasst von: Ebrahimi-Fakhari, Darius [VerfasserIn]
• Verfasst von: McLean, Pamela J. [VerfasserIn]
• Verfasst von: Unni, Vivek K. [VerfasserIn]
• Titel: Alpha-synuclein’s degradation in vivo
• Verf.angabe: Darius Ebrahimi-Fakhari, Pamela J. McLean & Vivek K. Unni
• E-Jahr: 2012
• Jahr: 01 Feb 2012
• Umfang: 3 S.
• Fussnoten: Gesehen am 16.04.2019
• Titel Quelle: Enthalten in: Autophagy
• Ort Quelle: Abingdon, Oxon : Taylor & Francis, 2005
• Jahr Quelle: 2012
• Band/Heft Quelle: 8(2012), 2, Seite 281-283
• ISSN Quelle: 1554-8635
• DOI: doi:10.4161/auto.8.2.18938
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: autophagy
• Sach-SW: degradation
• Sach-SW: in vivo
• Sach-SW: Lewy bodies
• Sach-SW: lysosome
• Sach-SW: multiphoton imaging
• Sach-SW: neurodegeneration
• Sach-SW: Parkinson disease
• Sach-SW: Proteasome
• Sach-SW: α-synuclein
• K10plus-PPN: 1663299463

Abstract

Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in α-synuclein's degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease.