Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Rühle, Alexander [VerfasserIn]   i
 Huber, Peter E. [VerfasserIn]   i
 Saffrich, Rainer [VerfasserIn]   i
Titel:The current understanding of mesenchymal stem cells as potential attenuators of chemotherapy-induced toxicity
Verf.angabe:Alexander Rühle, Peter E. Huber, Rainer Saffrich, Ramon Lopez Perez and Nils H. Nicolay
Jahr:2018
Jahr des Originals:2017
Umfang:12 S.
Fussnoten:Online 22 June 2017 ; Gesehen am 25.04.2019
Titel Quelle:Enthalten in: International journal of cancer
Ort Quelle:Bognor Regis : Wiley-Liss, 1966
Jahr Quelle:2018
Band/Heft Quelle:143(2018), 11, Seite 2628-2639
ISSN Quelle:1097-0215
Abstract:Chemotherapeutic agents are part of the standard treatment algorithms for many malignancies; however, their application and dosage are limited by their toxic effects to normal tissues. Chemotherapy-induced toxicities can be long-lasting and may be incompletely reversible; therefore, causative therapies for chemotherapy-dependent side effects are needed, especially considering the increasing survival rates of treated cancer patients. Mesenchymal stem cells (MSCs) have been shown to exhibit regenerative abilities for various forms of tissue damage. Preclinical data suggest that MSCs may also help to alleviate tissue lesions caused by chemotherapeutic agents, mainly by establishing a protective microenvironment for functional cells. Due to the systemic administration of most anticancer agents, the effects of these drugs on the MSCs themselves are of crucial importance to use stem cell-based approaches for the treatment of chemotherapy-induced tissue toxicities. Here, we present a concise review of the published data regarding the influence of various classes of chemotherapeutic agents on the survival, stem cell characteristics and physiological functions of MSCs. Molecular mechanisms underlying the effects are outlined, and resulting challenges of MSC-based treatments for chemotherapy-induced tissue injuries are discussed.
DOI:doi:10.1002/ijc.31619
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/ijc.31619
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31619
 DOI: https://doi.org/10.1002/ijc.31619
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:chemotherapy
 mesenchymal stem cells
 side effects
 tumors
K10plus-PPN:1663625190
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68382563   QR-Code
zum Seitenanfang