| Online-Ressource |
Verfasst von: | Wälscher, Julia [VerfasserIn]  |
| Groß, Benjamin [VerfasserIn]  |
| Eberhardt, Ralf [VerfasserIn]  |
| Heußel, Claus Peter [VerfasserIn]  |
| Eichinger, Monika [VerfasserIn]  |
| Lasitschka, Felix [VerfasserIn]  |
| Herth, Felix [VerfasserIn]  |
| Kreuter, Michael [VerfasserIn]  |
Titel: | Transbronchial cryobiopsies for diagnosing interstitial lung disease |
Titelzusatz: | real-life experience from a tertiary referral center for interstitial lung disease |
Verf.angabe: | Julia Wälscher, Benjamin Groß, Ralf Eberhardt, Claus Peter Heussel, Monika Eichinger, Arne Warth, Felix Lasitschka, Felix J.F. Herth, Michael Kreuter |
E-Jahr: | 2019 |
Jahr: | February 2019 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 26.04.2019 |
Titel Quelle: | Enthalten in: Respiration |
Ort Quelle: | Basel : Karger, 1968 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 97(2019), 4, Seite 348-354 |
ISSN Quelle: | 1423-0356 |
Abstract: | BACKGROUND: Transbronchial cryobiopsy (cTBB) may offer an alternative to surgical lung biopsy (SLB) for histopathological diagnosis of interstitial lung diseases (ILDs). However, real-life experience is limited, although case series are increasingly reported. - OBJECTIVES: We aimed to evaluate the value of cTBB performed under real-life conditions in a tertiary care center for ILDs. - METHODS: Data on all patients undergoing a cTBB for evaluation of suspected ILD between October 2015 and January 2017 were included in this retrospective case series. Procedure details, complication rates, histopathological results, and diagnostic consensus reached by a multidisciplinary team (MDT) discussion were collated and evaluated. - RESULTS: A total of 109 patients (mean age 64 years, range 19-85; 66% male, 38% never smokers) referred to our center with features suggestive of ILD underwent cTBB. The mean FVC% predicted was 77% (range 41-131), with a mean DLCO of 51% (range 20-86), and a 6-min walking test (6MWT) of 402 m (range 100-642). On average, 4 samples were taken from each patient (range 1-8), with a mean biopsy diameter of 5 mm (range 2-12). Complications included pneumothorax (11.9%), all treated with chest drain. Moderate bleeding occurred in 28.4% (all resolved without active measures). No acute disease exacerbations and no deaths occurred. A histopathological pattern diagnosis was possible in 80 cases (73.4%), and 26.6% of cases were considered nonspecific. An MDT consensus diagnosis was reached in 83.5% of cases. Subsequent SLB was proposed in 13 cases and performed in 8 cases. - CONCLUSIONS: In the real-world setting, cTBB has a meaningful diagnostic value in the context of a MDT approach and may enable histopathological assessment even in patients with more advanced disease unsuitable for SLB. |
DOI: | doi:10.1159/000493428 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1159/000493428 |
| DOI: https://doi.org/10.1159/000493428 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Bronchoscopy |
| Cryobiopsy |
| Interstitial lung disease |
| Multidisciplinary team |
K10plus-PPN: | 1663651280 |
Verknüpfungen: | → Zeitschrift |
Transbronchial cryobiopsies for diagnosing interstitial lung disease / Wälscher, Julia [VerfasserIn]; February 2019 (Online-Ressource)