| |  Online-Ressource |
|---|
| Verfasst von: | Aguilera, Luis U. [VerfasserIn]  |
|---|
| | Bergmann, Frank T. [VerfasserIn] |
|---|
| | Dalmasso, Giovanni [VerfasserIn] |
|---|
| | Großeholz, Ruth [VerfasserIn] |
|---|
| | Holzheu, Pascal [VerfasserIn] |
|---|
| | Kalra, Priyata [VerfasserIn] |
|---|
| | Kummer, Ursula [VerfasserIn] |
|---|
| | Sahle, Sven [VerfasserIn] |
|---|
| | Veith, Nadine [VerfasserIn] |
|---|
| | Elsässer, Tobias [VerfasserIn] |
|---|
| | Elmas, Sinan [VerfasserIn] |
|---|
| Titel: | Robustness of frequency vs. amplitude coding of calcium oscillations during changing temperatures |
|---|
| Verf.angabe: | Luis Aguilera, Frank T. Bergmann, Giovanni Dalmasso, Sinan Elmas, Tobias Elsässer, Ruth Großeholz, Pascal Holzheu, Priyata Kalra, Ursula Kummer, Sven Sahle, Nadine Veith |
|---|
| Jahr: | 2019 |
|---|
| Jahr des Originals: | 2018 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Available online 26 November 2018 ; Gesehen am 09.05.2019 |
|---|
| Titel Quelle: | Enthalten in: Biophysical chemistry |
|---|
| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1973 |
|---|
| Jahr Quelle: | 2019 |
|---|
| Band/Heft Quelle: | 245(2019), Seite 17-24 |
|---|
| ISSN Quelle: | 1873-4200 |
|---|
| Abstract: | Intracellular calcium oscillations have been widely studied. It is assumed that information is conveyed in the frequency, amplitude and shape of these oscillations. In particular, calcium signalling in mammalian liver cells has repeatedly been reported to display frequency coding so that an increasing amount of stimulus is translated into an increasing frequency of the oscillations. However, recently, we have shown that calcium oscillations in fish liver cells rather exhibit amplitude coding with increasing stimuli being translated into increasing amplitudes. Practical consequences of this difference are unknown so far. Here we investigated advantages and disadvantages of frequency vs. amplitude coding, in particular in environments with substantially changing temperatures (e.g. 10-20 degrees). For this purpose, we use computational modelling and a new approach to generate a calcium model exactly displaying a specific frequency and/or amplitude. We conclude that despite the advantages in flexibility that frequencies might offer for the transmission of information in the cell, amplitude coding is obviously more robust with respect to changes in environmental temperatures. This potentially explains the observed differences between two classes of organisms, one operating at constant temperatures whereas the other is not. |
|---|
| DOI: | doi:10.1016/j.bpc.2018.11.003 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.bpc.2018.11.003 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0301462218302552 |
|---|
| | DOI: https://doi.org/10.1016/j.bpc.2018.11.003 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Calcium oscillations |
|---|
| | Decoding |
|---|
| | Hepatocytes |
|---|
| | Temperature dependence |
|---|
| K10plus-PPN: | 1663673012 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Robustness of frequency vs. amplitude coding of calcium oscillations during changing temperatures / Aguilera, Luis U. [VerfasserIn]; 2019 (Online-Ressource)
