Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Toubai, Tomomi [VerfasserIn]  |
| Rossi, Corinne [VerfasserIn]  |
Titel: | Murine models of steroid refractory graft-versus-host disease |
Verf.angabe: | Tomomi Toubai, Corinne Rossi, Isao Tawara, Chen Liu, Cynthia Zajac, Katherine Oravecz-Wilson, Daniel Peltier, Yaping Sun, Hideaki Fujiwara, Shin-Rong Wu, Mary Riwes, Israel Henig, Stephanie Kim and Pavan Reddy |
E-Jahr: | 2018 |
Jahr: | 20 August 2018 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 26.04.2019 |
Titel Quelle: | Enthalten in: Scientific reports |
Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 8(2018) Article number: 12475, 10 Seiten |
ISSN Quelle: | 2045-2322 |
Abstract: | Corticosteroids are the first line therapy for acute graft-versus-host disease (GVHD). However, the outcome of steroid refractory GVHD (SR-GVHD) is poor due to a lack of effective treatments. The development of therapies for SR-GVHD is limited by an incomplete understanding of its pathophysiology partly because of the absence of clinically relevant animal models of SR-GVHD. Here we addressed the need for a SR-GVHD animal model by developing both MHC matched multiple minor histocompatibility antigens (miHAs) mismatched and MHC mismatched haploidentical murine models of SR-GVHD. We demonstrate that animals can develop SR-GVHD regardless of whether steroids are initiated early or late post allogeneic bone marrow transplantation (allo-BMT). In general, we observed increased GVHD specific histopathological damage of target organs in SR-GVHD animals relative to steroid responsive animals. Interestingly, we found no significant differences in donor T cell characteristics between steroid refractory and responsive animals suggesting that donor T cell independent mechanisms may play more prominent roles in the pathogenesis of SR-GVHD than was considered previously. |
DOI: | doi:10.1038/s41598-018-30814-x |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41598-018-30814-x |
| Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102256/ |
| DOI: https://doi.org/10.1038/s41598-018-30814-x |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1663689822 |
Verknüpfungen: | → Zeitschrift |
Murine models of steroid refractory graft-versus-host disease / Toubai, Tomomi [VerfasserIn]; 20 August 2018 (Online-Ressource)
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