Whole-body MR imaging including angiography

• Verfasst von: Bertheau, Robert [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Schönberg, Stefan [VerfasserIn]
• Verfasst von: Weckbach, Sabine [VerfasserIn]
• Verfasst von: Schlett, Christopher L. [VerfasserIn]
• Titel: Whole-body MR imaging including angiography
• Titelzusatz: predicting recurrent events in diabetics
• Verf.angabe: Robert C. Bertheau, Fabian Bamberg, Elena Lochner, Hannes M. Findeisen, Klaus G. Parhofer, Hans-Ulrich Kauczor, Stefan O. Schoenberg, Sabine Weckbach, Christopher L. Schlett
• Jahr: 2016
• Jahr des Originals: 2015
• Umfang: 11 S.
• Fussnoten: Gesehen am 29.04.2019 ; Published online: 25 August 2015
• Titel Quelle: Enthalten in: European radiology
• Ort Quelle: Berlin : Springer, 1991
• Jahr Quelle: 2016
• Band/Heft Quelle: 26(2016), 5, Seite 1420-1430
• ISSN Quelle: 1432-1084
• ISSN Quelle: 1613-3757
• DOI: doi:10.1007/s00330-015-3936-4
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Diabetes mellitus
• Sach-SW: Anatomical relatedness
• Sach-SW: Prediction
• Sach-SW: Recurrent events
• Sach-SW: Whole-body magnetic resonance imaging
• K10plus-PPN: 1663719578

Abstract

Objectives: Whether whole-body MRI can predict occurrence of recurrent events in patients with diabetes mellitus. Methods: Whole-body MRI was prospectively applied to 61 diabetics and assessed for arteriosclerosis and ischemic cerebral/myocardial changes. Occurrence of cardiocerebral events and diabetic comorbidites was determined. Patients were stratified whether no, a single or recurrent events arose. As a secondary endpoint, events were stratified into organ system-specific groups. Results: During a median follow-up of 70 months, 26 diabetics developed a total of 39 events; 18 (30 %) developed one, 8 (13 %) recurrent events. Between diabetics with no, a single and recurrent events, a stepwise higher burden was observed for presence of left ventricular (LV) hypo-/akinesia (3/28/75 %, p < 0.0001), myocardial delayed-contrast-enhancement (17/33/63 %, p = 0.001), carotid artery stenosis (11/17/63 %, p = 0.005), peripheral artery stenosis (26/56/88 %, p = 0.0006) and vessel score (1.00/1.30/1.76, p < 0.0001). After adjusting for clinical characteristics, LV hypo-/akinesia (hazard rate ratio = 6.57, p < 0.0001) and vessel score (hazard rate ratio = 12.29, p < 0.0001) remained independently associated. Assessing organ system risk, cardiac and cerebral MR findings predicted more strongly events in their respective organ system. Vessel-score predicted both cardiac and cerebral, but not non-cardiocerebral, events. Conclusion: Whole-body MR findings predict occurrence of recurrent events in diabetics independent of clinical characteristics, and may concurrently provide organ system-specific risk.