Magnesium as an intrinsic component of human otoconia

• Verfasst von: Walther, Leif Erik [VerfasserIn]
• Titel: Magnesium as an intrinsic component of human otoconia
• Verf.angabe: Leif Erik Walther, Jana Wulfes, Alexander Blödow, Rüdiger Kniep
• E-Jahr: 2018
• Jahr: 15 May 2018
• Umfang: 4 S.
• Fussnoten: Gesehen am 29.04.2019
• Titel Quelle: Enthalten in: Acta oto-laryngologica
• Ort Quelle: Stockholm : Taylor & Francis Group, 1918
• Jahr Quelle: 2018
• Band/Heft Quelle: 138(2018), 9, Seite 775-778
• ISSN Quelle: 1651-2251
• DOI: doi:10.1080/00016489.2018.1467572
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: calcite substitution
• Sach-SW: calcium
• Sach-SW: Calcium
• Sach-SW: calcium carbonate
• Sach-SW: Calcium Carbonate
• Sach-SW: Crystallization
• Sach-SW: Electron Probe Microanalysis
• Sach-SW: Humans
• Sach-SW: In Vitro Techniques
• Sach-SW: magnesium
• Sach-SW: Magnesium
• Sach-SW: otoconia
• Sach-SW: Otolith organs
• Sach-SW: Otolithic Membrane
• Sach-SW: saccule
• Sach-SW: utricle
• K10plus-PPN: 1663721572

Abstract

OBJECTIVES: To investigate morphology changes of artificial otoconia (CGC) in the presence of magnesium during growth under in vitro conditions. - METHODS: Investigating human otoconia by environmental scanning electron microscope and determining their magnesium content by energy-dispersive X-ray microanalysis (EDX). Comparing structural and morphological data of human and artificial otoconia (CGC, Ca1Mg0) without and with magnesium substitution (Ca1-xMgx). - RESULTS: EDX- and X-ray data reveals that the inorganic component in human otoconia consists of calcite containing a minor amount of magnesium substitution (Ca1-xMgx). CGC containing magnesium (length 397.0 ± 146.4 µm, diameter 325.6 ± 100.1 µm) are slimmer and significantly smaller (p < .01) than pure CGC (length 548.6 ± 160 µm, diameter 373.0 ± 110.4 µm) and reveal a significant influence on the final morphology. The length/diameter ratio is significantly higher by incorporation of magnesium into CGC (1.84 ± 0.25 µm versus 1.48 ± 0.11 µm in pure CGC, p < .01), which brings the overall shape to a close relationship with human otoconia (1.98 ± 0.08 µm). - CONCLUSIONS: Magnesium is an intrinsic component of human otoconia by partial substitution of calcium in the calcite crystal structure (Ca1-xMgx) and affects the development of the shape of artificial otoconia (calcite gelatin composites, CGC).