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Verfasst von:Bischof, Lisa [VerfasserIn]   i
 Jakobi, Tobias [VerfasserIn]   i
Titel:Early response of Sulfolobus acidocaldarius to nutrient limitation
Verf.angabe:Lisa F. Bischof, M. Florencia Haurat, Lena Hoffmann, Andreas Albersmeier, Jacqueline Wolf, Astrid Neu, Trong Khoa Pham, Stefan P. Albaum, Tobias Jakobi, Stefan Schouten, Meina Neumann-Schaal, Phillip C. Wright, Jörn Kalinowski, Bettina Siebers and Sonja-Verena Albers
E-Jahr:2019
Jahr:10 January 2019
Umfang:17 S.
Fussnoten:Gesehen am 03.05.2019
Titel Quelle:Enthalten in: Frontiers in Cellular and Infection Microbiology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2019
Band/Heft Quelle:9(2019) Artikel-Nummer 3201, 17 Seiten
ISSN Quelle:2235-2988
Abstract:In natural environments microorganisms encounter extreme changes in temperature, pH, osmolarities and nutrient availability. The stress response of many bacterial species has been described in detail, however, knowledge in Archaea is limited. Here, we describe the cellular response triggered by nutrient limitation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius. We measured changes in gene transcription and protein abundance upon nutrient depletion up to 4 h after initiation of nutrient depletion. Transcript abundance of 1118 of 2223 protein coding genes and levels of approximately 500 proteins with functions in almost all cellular processes were affected by nutrient depletion. Our study reveals a significant rerouting of the metabolism with respect to degradation of internal as well as extracellular-bound organic carbon and degradation of proteins. Moreover, changes in membrane lipid composition were observed in order to access alternative sources of energy and to maintain pH homeostasis. At transcript level, the cellular response to nutrient depletion in S. acidocaldarius seems to be controlled by the general transcription factors TFB2 and TFEβ. In addition, ribosome biogenesis is reduced, while an increased protein degradation is accompanied with a loss of protein quality control. This study provides first insights into the early cellular response of Sulfolobus to organic carbon and organic nitrogen depletion.
DOI:doi:10.3389/fmicb.2018.03201
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3389/fmicb.2018.03201
 Volltext: https://www.frontiersin.org/articles/10.3389/fmicb.2018.03201/full
 DOI: https://doi.org/10.3389/fmicb.2018.03201
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Archaea
 motility
 Nutrient depletion
 Signal Transduction
 stress response
 Transcription Factors
K10plus-PPN:166453928X
Verknüpfungen:→ Zeitschrift

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