Status: Bibliographieeintrag
Standort: ---
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| Online-Ressource |
Verfasst von: | Weinkauf, Benjamin [VerfasserIn]  |
| Obreja, Otilia [VerfasserIn]  |
| Schmelz, Martin [VerfasserIn]  |
| Rukwied, Roman [VerfasserIn]  |
Titel: | Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans |
Verf.angabe: | B. Weinkauf, O. Obreja, M. Schmelz, R. Rukwied |
E-Jahr: | 2012 |
Jahr: | 06 March 2012 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 07.05.2019 |
Titel Quelle: | Enthalten in: European journal of pain |
Ort Quelle: | Malden, Mass. [u.a.] : Wiley-Blackwell, 1997 |
Jahr Quelle: | 2012 |
Band/Heft Quelle: | 16(2012), 4, Seite 543-549 |
ISSN Quelle: | 1532-2149 |
Abstract: | We investigated the effects of a non-specific sodium channel blocker (lidocaine) on heat pain thresholds and mechanical impact pain at day 7 and 21 after intradermal injection of 1 μg NGF. Measurements were performed in 12 healthy male subjects prior to and 5 min after intradermal injection of 150 μl lidocaine administered at concentrations of 0.01% (∼0.4 mM) and 0.1% (∼4 mM) to both NGF and control skin sites. NGF caused a maximum reduction of heat pain thresholds at day 7 (NGF 42.6 ± 0.6 vs. 49.4 ± 0.3 °C in control skin). Lidocaine sensitized normal skin for heat pain, but reduced heat hyperalgesia after NGF at day 7 (44.3 ± 0.8 °C, lidocaine 0.1%; p < 0.005). Pain upon supra-threshold mechanical impact stimulation was increased after NGF at day 7 (VAS 29 + 5) and massively enhanced at day 21 (VAS 64 + 5, p < 0.001). Lidocaine dose-dependently attenuated mechanically-induced pain at both control and NGF-treated sites. Maximum lidocaine effects on mechanical hyperalgesia were recorded at day 21 in NGF skin (pain reduction to VAS 37 ± 4, p < 0.00001). Repetitive impact stimuli caused increasingly more pain at the NGF sites at day 21 and this pain increase was efficiently suppressed by lidocaine 0.1%. Lidocaine differentially affects NGF-induced mechanical hyperalgesia (analgesic effect) and heat sensitivity of nociceptors (sensitizing effect). These opposing responses may be attributed to block of sodium channels vs. sensitization of TRPV1. NGF-evoked extreme mechanical impact pain indicates high action potential discharge frequencies, which might be more susceptible to lidocaine block. |
DOI: | doi:10.1016/j.ejpain.2011.08.004 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejpain.2011.08.004 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/j.ejpain.2011.08.004 |
| DOI: https://doi.org/10.1016/j.ejpain.2011.08.004 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1664848800 |
Verknüpfungen: | → Zeitschrift |
Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans / Weinkauf, Benjamin [VerfasserIn]; 06 March 2012 (Online-Ressource)
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