Transvascular therapy of Hepatocellular Carcinoma (HCC), status and developments

• Verfasst von: Gnutzmann, Daniel [VerfasserIn]
• Verfasst von: Weiss, Karl Heinz [VerfasserIn]
• Titel: Transvascular therapy of Hepatocellular Carcinoma (HCC), status and developments
• Verf.angabe: Daniel Gnutzmann, Nikolas Kortes, Migle Sumkauskaite, Anne Schmitz, Karl-Heinz Weiss, Boris Radeleff
• E-Jahr: 2018
• Jahr: 30 Jan 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 07.05.2019
• Titel Quelle: Enthalten in: Minimally invasive therapy & allied technologies
• Ort Quelle: Abingdon : Taylor & Francis Group, 1996
• Jahr Quelle: 2018
• Band/Heft Quelle: 27(2018), 2, Seite 69-80
• ISSN Quelle: 1365-2931
• DOI: doi:10.1080/13645706.2018.1432489
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Conventional TransArterial ChemoEmbolization
• Sach-SW: drug-eluting beads
• Sach-SW: embolization
• Sach-SW: hepatocellular carcinoma
• Sach-SW: Lipiodol
• K10plus-PPN: 1664883681

Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Only 30-40% of patients diagnosed with HCC are candidates for curative treatment options. The remaining majority of patients undergo local, regional or systemic palliative therapies. Transvascular therapy of HCC takes advantage of the fact that hypervascularized HCCs receive their main perfusion from the hepatic artery. In this context transvascular therapy describes different therapies: bland embolization (transarterial embolization, TAE), cTACE (conventional transarterial chemoembolization), DEB-TACE (TACE with drug-eluting beads, DEB) and SIRT (selective internal radiation therapy, radioembolization). cTACE is the most common type of transvascular treatment and represents a combination of the intra-arterial use of a chemotherapeutic agent and embolization. There is no standardized regimen for cTACE. It remains unclear whether the intra-arterial application of a chemotherapeutic agent is definitely required, because bland embolization alone using very small spherical particles shows tumor necrosis comparable to cTACE. For DEB-TACE microparticles loaded with a chemotherapeutic drug combine the advantages of cTACE and bland embolization.