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| Verfasst von: | Kühn, Simone [VerfasserIn]  |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Mann, Karl [VerfasserIn] |
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| | Rietschel, Marcella [VerfasserIn] |
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| Titel: | From mother to child |
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| Titelzusatz: | orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence |
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| Verf.angabe: | Simone Kühn, Charlotte Witt, Tobias Banaschewski, Alexis Barbot, Gareth J. Barker, Christian Büchel, Patricia J. Conrod, Herta Flor, Hugh Garavan, Bernd Ittermann, Karl Mann, Jean-Luc Martinot, Tomas Paus, Marcella Rietschel, Michael N. Smolka, Andreas Ströhle, Rüdiger Brühl, Gunter Schumann, Andreas Heinz, Jürgen Gallinat and the IMAGEN Consortium |
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| Jahr: | 2016 |
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| Jahr des Originals: | 2015 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 08.05.2019 ; First published: 24 April 2015 |
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| Titel Quelle: | Enthalten in: Addiction biology |
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| Ort Quelle: | Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 21(2016), 3, Seite 700-708 |
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| ISSN Quelle: | 1369-1600 |
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| Abstract: | Adolescence is a common time for initiation of alcohol use and alcohol use disorders. Importantly, the neuro-anatomical foundation for later alcohol-related problems may already manifest pre-natally, particularly due to smoking and alcohol consumption during pregnancy. In this context, cortical gyrification is an interesting marker of neuronal development but has not been investigated as a risk factor for adolescent alcohol use. On magnetic resonance imaging scans of 595 14-year-old adolescents from the IMAGEN sample, we computed whole-brain mean curvature indices to predict change in alcohol-related problems over the following 2 years. Change of alcohol use-related problems was significantly predicted from mean curvature in left orbitofrontal cortex (OFC). Less gyrification of OFC was associated with an increase in alcohol use-related problems over the next 2 years. Moreover, lower gyrification in left OFC was related to pre-natal alcohol exposure, whereas maternal smoking during pregnancy had no effect. Current alcohol use-related problems of the biological mother had no effect on offsprings' OFC gyrification or drinking behaviour. The data support the idea that alcohol consumption during pregnancy mediates the development of neuro-anatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in a vulnerable stage of life. Maternal smoking during pregnancy or current maternal alcohol/nicotine consumption had no significant effect. The OFC mediates behaviours known to be disturbed in addiction, namely impulse control and reward processing. The results stress the importance of pre-natal alcohol exposure for later increases in alcohol use-related problems, mediated by structural brain characteristics. |
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| DOI: | doi:10.1111/adb.12240 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1111/adb.12240 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12240 |
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| | DOI: https://doi.org/10.1111/adb.12240 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adolescence |
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| | alcohol use |
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| | dependence |
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| | gyrification |
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| | maternal drinking |
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| K10plus-PPN: | 1665018607 |
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| Verknüpfungen: | → Zeitschrift |
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