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Verfasst von:Tay, Nicole [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
 Nees, Frauke [VerfasserIn]   i
 Hohmann, Sarah [VerfasserIn]   i
Titel:Allele-specific methylation of SPDEF
Titelzusatz:a novel moderator of psychosocial stress and substance abuse
Verf.angabe:Nicole Tay, Christine Macare, Yun Liu, Barbara Ruggeri, Tianye Jia, Congying Chu, Francesca Biondo, Alex Ing, Qiang Luo, Daniil Sarkysian, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Helge Frieling, Stefan Bleich, Edward D. Barker, Ann-Christine Syvänen, Joëlle Rüegg, Tomas J. Ekström, Georgy Bakalkin, Gunter Schumann
Jahr:2019
Jahr des Originals:2018
Umfang:10 S.
Fussnoten:Published:11 Dec 2018 ; Gesehen am 09.05.2019
Titel Quelle:Enthalten in: The American journal of psychiatry
Ort Quelle:Stanford, Calif. : HighWire Press, 1844
Jahr Quelle:2019
Band/Heft Quelle:176(2019), 2, Seite 146-155
ISSN Quelle:1535-7228
Abstract:Objective:Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide methylation analysis to investigate whether differentially methylated regions are associated with psychosocial stress in an adolescent population.Methods:A methylome-wide analysis of differentially methylated regions was used to examine a sample of 1,287 14-year-old adolescents (50.7% of them female) from the European IMAGEN study. The Illumina 450k array was used to assess DNA methylation, pyrosequencing was used for technical replication, and linear regression analyses were used to identify associations with psychosocial stress and substance use (alcohol and tobacco). Findings were replicated by pyrosequencing a test sample of 413 participants from the IMAGEN study.Results:Hypermethylation in the sterile alpha motif/pointed domain containing the ETS transcription factor (SPDEF) gene locus was associated with a greater number of stressful life events in an allele-dependent way. Among individuals with the minor G-allele, SPDEF methylation moderated the association between psychosocial stress and substance abuse. SPDEF methylation interacted with lifetime stress in gray matter volume in the right cuneus, which in turn was associated with the frequency of alcohol and tobacco use. SPDEF was involved in the regulation of trans-genes linked to substance use.Conclusions:Taken together, the study findings describe a novel epigenetic mechanism that helps explain how psychosocial stress exposure influences adolescent substance abuse.
DOI:doi:10.1176/appi.ajp.2018.17121360
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1176/appi.ajp.2018.17121360
 Volltext: https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.17121360
 DOI: https://doi.org/10.1176/appi.ajp.2018.17121360
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1665050039
Verknüpfungen:→ Zeitschrift

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