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Status: Bibliographieeintrag

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Verfasst von:Mallien, Anne Stephanie [VerfasserIn]   i
 Inta, Dragos [VerfasserIn]   i
 Vollmayr, Barbara [VerfasserIn]   i
 Gass, Peter [VerfasserIn]   i
Titel:Daily exposure to a touchscreen-paradigm and associated food restriction evokes an increase in adrenocortical and neural activity in mice
Verf.angabe:Anne Stephanie Mallien, Rupert Palme, Juliet Richetto, Chiara Muzzillo, Sophie Helene Richter, Miriam Annika Vogt, Dragos Inta, Marco Andrea Riva, Barbara Vollmayr, Peter Gass
E-Jahr:2016
Jahr:6 April 2016
Umfang:9 S.
Fussnoten:Gesehen am 09.05.2019
Titel Quelle:Enthalten in: Hormones and behavior
Ort Quelle:Orlando, Fla. : Acad. Press, 1969
Jahr Quelle:2016
Band/Heft Quelle:81(2016), Seite 97-105
ISSN Quelle:1095-6867
Abstract:The translational assessment of mechanisms underlying cognitive functions using touchscreen-based approaches for rodents is growing in popularity. In these paradigms, daily training is usually accompanied by extended food restriction to maintain animals' motivation to respond for rewards. Here, we show a transient elevation in stress hormone levels due to food restriction and touchscreen training, with subsequent adaptation effects, in fecal corticosterone metabolite concentrations, indicating effective coping in response to physical and psychological stressors. Corticosterone concentrations of experienced but training-deprived mice revealed a potential anticipation of task exposure, indicating a possible temporary environmental enrichment-like effect caused by cognitive challenge. Furthermore, the analyses of immediate early gene (IEG) immunoreactivity in the hippocampus revealed alterations in Arc, c-Fos and zif268 expression immediately following training. In addition, BDNF expression was altered as a function of satiation state during food restriction. These findings suggest that standard protocols for touchscreen-based training induce changes in hippocampal neuronal activity related to satiation and learning that should be considered when using this paradigm.
DOI:doi:10.1016/j.yhbeh.2016.03.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.yhbeh.2016.03.009
 Volltext: http://www.sciencedirect.com/science/article/pii/S0018506X1530129X
 DOI: https://doi.org/10.1016/j.yhbeh.2016.03.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Mice
 BDNF
 Corticosterone concentration
 Food restriction
 Hippocampus
 Immediate early genes
 Stress
 Touchscreen chambers
 Translation
K10plus-PPN:1665054662
Verknüpfungen:→ Zeitschrift

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