Agalsidase alfa and kidney dysfunction in Fabry disease

• Verfasst von: West, Michael [VerfasserIn]
• Verfasst von: Ries, Markus [VerfasserIn]
• Titel: Agalsidase alfa and kidney dysfunction in Fabry disease
• Verf.angabe: Michael West, Kathy Nicholls, Atul Mehta, Joe T.R. Clarke, Robert Steiner, Michael Beck, Bruce A. Barshop, William Rhead, Robert Mensah, Markus Ries, Raphael Schiffmann
• E-Jahr: 2009
• Jahr: May 2009
• Umfang: 8 S.
• Fussnoten: Gesehen am 09.05.2019
• Titel Quelle: Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology
• Ort Quelle: Washington, DC : American Society of Nephrology, 1990
• Jahr Quelle: 2009
• Band/Heft Quelle: 20(2009), 5, Seite 1132-1139
• ISSN Quelle: 1533-3450
• DOI: doi:10.1681/ASN.2008080870
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1665086580

Abstract

In male patients with Fabry disease, an X-linked disorder of glycosphingolipid metabolism caused by deficient activity of the lysosomal enzyme α-galactosidase A, kidney dysfunction becomes apparent by the third decade of life and invariably progresses to ESRD without treatment. Here, we summarize the effects of agalsidase alfa on kidney function from three prospective, randomized, placebo-controlled trials and their open-label extension studies involving 108 adult male patients. The mean baseline GFR among 54 nonhyperfiltrating patients (measured GFR <135 ml/min per 1.73 m2) treated with placebo was 85.4 ± 29.6 ml/min per 1.73 m2; during 6 mo of placebo, the mean annualized rate of change in GFR was −7.0 ± 32.9 ml/min per 1.73 m2. Among 85 nonhyperfiltrating patients treated with agalsidase alfa, the annualized rate of change was −2.9 ± 8.7 ml/min per 1.73 m2. Treatment with agalsidase alfa did not affect proteinuria. Multivariate analysis revealed that GFR and proteinuria category (<1 or ≥1 g/d) at baseline significantly predicted the rate of decline of GFR during treatment. This summary represents the largest group of male patients who had Fabry disease and for whom the effects of enzyme replacement therapy on kidney function have been studied. These data suggest that agalsidase alfa may stabilize kidney function in these patients.