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Verfasst von:Brecht, Susan [VerfasserIn]   i
 Boda-Heggemann, Judit [VerfasserIn]   i
 Budjan, Johannes [VerfasserIn]   i
 Siebenlist, Kerstin [VerfasserIn]   i
 Stieler, Florian [VerfasserIn]   i
 Steil, Volker [VerfasserIn]   i
 Wenz, Frederik [VerfasserIn]   i
 Bürgy, Daniel [VerfasserIn]   i
Titel:Radiation-induced optic neuropathy after stereotactic and image guided intensity-modulated radiation therapy (IMRT)
Verf.angabe:Susan Brecht, Judit Boda-Heggemann, Johannes Budjan, Kerstin Siebenlist, Florian Stieler, Volker Steil, Frederik Wenz, Frank Lohr, Daniel Buergy
E-Jahr:2019
Jahr:18 February 2019
Umfang:12 S.
Fussnoten:Gesehen am 13.05.2019
Titel Quelle:Enthalten in: Radiotherapy and oncology
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1983
Jahr Quelle:2019
Band/Heft Quelle:134(2019), Seite 166-177
ISSN Quelle:1879-0887
Abstract:Background/purpose - To quantify the risk of radiation-induced optic neuropathy (RION) after stereotactic/image-guided positioning and intensity-modulated radiotherapy (IMRT) with ≥50Gy to the anterior visual pathway (AVP). - Methods - Patients irradiated with ≥50Gy to the AVP using stereotactic/image-guided positioning between 2002 and 2011 in Mannheim were identified. Detailed dosimetric data were collected and patients or family members were retrospectively asked to rate visual acuity and visual disorders. - Results - 125 patients fulfilled the eligibility criteria. Average maximum equivalent point dose (Dmax-EQD-2[α/β=1.6]) to the AVP was 53.1±3.9Gy. 99 patients received ≥50Gy bilaterally (chiasm or both optic nerves), resulting in 224 (99x2 bilateral plus 26 unilateral) visual-fields-at-risk (VFAR) for RION. Eighty-two patients provided pre/post-IMRT visual status information (n=151 VFARs). Permanent visual deterioration occurred in 18 (22%) patients. In seven, visual deterioration was possibly related to radiotherapy (two-sided deterioration in one patient) for a crude incidence of 8.5% (7/82 patients) and 5.3% (8/151 VFARs). Two cases were caused by chronic keratitis/conjunctivitis; in five patients RION could not be excluded (one two-sided). In one of 13 patients with Dmax-EQD-2>58Gy, RION could not be excluded. In all affected patients, visual acuity post-IMRT had decreased only mildly (1-2 points on the 5-point-scale). One patient with relevant baseline visual impairment (3/5) developed unilateral blindness (crude incidence of blindness on patient-/VFAR-level: 1.2% and 0.66%; competing risk-adjusted/actuarial 24-month incidence: patient/VFAR-level: 1.8% and 0.95%). - Conclusion - Risk of RION was low in this cohort with accurate positioning and precise dosimetric information. Less conservative tolerance doses may be considered in patients with high risk of recurrence.
DOI:doi:10.1016/j.radonc.2019.02.003
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.radonc.2019.02.003
 Volltext: http://www.sciencedirect.com/science/article/pii/S0167814019300696
 DOI: https://doi.org/10.1016/j.radonc.2019.02.003
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:IMRT-image-guided/stereotactic repositioning
 Radiation-induced optic neuropathy
 Radiation-induced toxicity
 RION
 Treatment-related toxicity
K10plus-PPN:1665272228
Verknüpfungen:→ Zeitschrift

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