| Online-Ressource |
Verfasst von: | Brecht, Susan [VerfasserIn]  |
| Boda-Heggemann, Judit [VerfasserIn]  |
| Budjan, Johannes [VerfasserIn]  |
| Siebenlist, Kerstin [VerfasserIn]  |
| Stieler, Florian [VerfasserIn]  |
| Steil, Volker [VerfasserIn]  |
| Wenz, Frederik [VerfasserIn]  |
| Bürgy, Daniel [VerfasserIn]  |
Titel: | Radiation-induced optic neuropathy after stereotactic and image guided intensity-modulated radiation therapy (IMRT) |
Verf.angabe: | Susan Brecht, Judit Boda-Heggemann, Johannes Budjan, Kerstin Siebenlist, Florian Stieler, Volker Steil, Frederik Wenz, Frank Lohr, Daniel Buergy |
E-Jahr: | 2019 |
Jahr: | 18 February 2019 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 13.05.2019 |
Titel Quelle: | Enthalten in: Radiotherapy and oncology |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1983 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 134(2019), Seite 166-177 |
ISSN Quelle: | 1879-0887 |
Abstract: | Background/purpose - To quantify the risk of radiation-induced optic neuropathy (RION) after stereotactic/image-guided positioning and intensity-modulated radiotherapy (IMRT) with ≥50Gy to the anterior visual pathway (AVP). - Methods - Patients irradiated with ≥50Gy to the AVP using stereotactic/image-guided positioning between 2002 and 2011 in Mannheim were identified. Detailed dosimetric data were collected and patients or family members were retrospectively asked to rate visual acuity and visual disorders. - Results - 125 patients fulfilled the eligibility criteria. Average maximum equivalent point dose (Dmax-EQD-2[α/β=1.6]) to the AVP was 53.1±3.9Gy. 99 patients received ≥50Gy bilaterally (chiasm or both optic nerves), resulting in 224 (99x2 bilateral plus 26 unilateral) visual-fields-at-risk (VFAR) for RION. Eighty-two patients provided pre/post-IMRT visual status information (n=151 VFARs). Permanent visual deterioration occurred in 18 (22%) patients. In seven, visual deterioration was possibly related to radiotherapy (two-sided deterioration in one patient) for a crude incidence of 8.5% (7/82 patients) and 5.3% (8/151 VFARs). Two cases were caused by chronic keratitis/conjunctivitis; in five patients RION could not be excluded (one two-sided). In one of 13 patients with Dmax-EQD-2>58Gy, RION could not be excluded. In all affected patients, visual acuity post-IMRT had decreased only mildly (1-2 points on the 5-point-scale). One patient with relevant baseline visual impairment (3/5) developed unilateral blindness (crude incidence of blindness on patient-/VFAR-level: 1.2% and 0.66%; competing risk-adjusted/actuarial 24-month incidence: patient/VFAR-level: 1.8% and 0.95%). - Conclusion - Risk of RION was low in this cohort with accurate positioning and precise dosimetric information. Less conservative tolerance doses may be considered in patients with high risk of recurrence. |
DOI: | doi:10.1016/j.radonc.2019.02.003 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.radonc.2019.02.003 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0167814019300696 |
| DOI: https://doi.org/10.1016/j.radonc.2019.02.003 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | IMRT-image-guided/stereotactic repositioning |
| Radiation-induced optic neuropathy |
| Radiation-induced toxicity |
| RION |
| Treatment-related toxicity |
K10plus-PPN: | 1665272228 |
Verknüpfungen: | → Zeitschrift |
Radiation-induced optic neuropathy after stereotactic and image guided intensity-modulated radiation therapy (IMRT) / Brecht, Susan [VerfasserIn]; 18 February 2019 (Online-Ressource)