The minimal important difference for target lobe volume reduction after endoscopic valve therapy

• Verfasst von: Gompelmann, Daniela [VerfasserIn]
• Verfasst von: Kontogianni, Konstantina [VerfasserIn]
• Verfasst von: Schuhmann, Maren [VerfasserIn]
• Verfasst von: Eberhardt, Ralf [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Titel: The minimal important difference for target lobe volume reduction after endoscopic valve therapy
• Verf.angabe: D. Gompelmann, K. Kontogianni, M. Schuhmann, R. Eberhardt, C.P. Heussel, F.J. Herth
• Jahr: 2018
• Umfang: 8 S.
• Teil: volume:13
• Teil: year:2018
• Teil: pages:465-472
• Teil: extent:8
• Fussnoten: Gesehen am 13.05.2019
• Titel Quelle: Enthalten in: The International journal of chronic obstructive pulmonary disease
• Ort Quelle: Albany, Auckland : DOVE Medical Press, 2006
• Jahr Quelle: 2018
• Band/Heft Quelle: 13(2018), Seite 465-472
• ISSN Quelle: 1178-2005
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1665275111

Abstract

Objective: Endoscopic valve therapy aims at target lobe volume reduction (TLVR) that is associated with improved lung function, exercise tolerance and quality of life in emphysema patients. So far, a TLVR of >350 mL was considered to be indicative of a positive response to treatment. However, it is not really known what amount of TLVR is crucial following valve implantation. Patients and methods: TLVR, forced expiratory volume in 1 second (FEV1), residual volume (RV) and 6-minute walk distance (6-MWD) were assessed before and 3 months after valve implantation in 119 patients. TLVR was calculated based on computed tomography (CT) scan analysis using imaging software (Apollo; VIDA Diagnostics). Minimal important difference estimates were calculated by anchor-based and distribution-based methods.Results: Patients treated with valves experienced a mean change of 0.11 L in FEV1, -0.51 L in RV, 44 m in 6-MWD and a TLVR of 945 mL. Using a linear regression and receiver operating characteristic analysis based on two of three anchors (ΔFEV1, ΔRV), the estimated minimal impor­tant difference for TLVR was between 890 and 1,070 mL (ie, 49%–54% of the baseline TLV). Conclusion: In future, a TLVR between 49% and 54% of the baseline TLV, should be used when interpreting the clinical relevance.