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| Verfasst von: | Breckwoldt, Michael O. [VerfasserIn]  |
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| | Sahm, Felix [VerfasserIn] |
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| | Solecki, Gergely [VerfasserIn] |
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| | Bergmeister-Berghoff, Anna Sophie [VerfasserIn] |
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| | Venkataramani, Varun [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Heiland, Sabine [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Kurz, Felix T. [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| | Hahn, Artur [VerfasserIn] |
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| | Haas, Maximilian [VerfasserIn] |
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| | Tews, Björn [VerfasserIn] |
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| Titel: | Correlated MRI and ultramicroscopy (MR-UM) of brain tumors reveals vast heterogeneity of tumor infiltration and neoangiogenesis in preclinical models and human disease |
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| Verf.angabe: | Michael O. Breckwoldt, Julia Bode, Felix Sahm, Thomas Krüwel, Gergely Solecki, Artur Hahn, Peter Wirthschaft, Anna S. Berghoff, Maximilian Haas, Varun Venkataramani, Andreas von Deimling, Wolfgang Wick, Christel Herold-Mende, Sabine Heiland, Michael Platten, Martin Bendszus, Felix T. Kurz, Frank Winkler and Björn Tews |
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| E-Jahr: | 2019 |
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| Jahr: | 10 January 2019 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 16.05.2019 |
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| Titel Quelle: | Enthalten in: Frontiers in neuroscience |
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| Ort Quelle: | Lausanne : Frontiers Research Foundation, 2007 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 12(2019) Artikel-Nummer 1004, 10 Seiten |
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| ISSN Quelle: | 1662-453X |
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| Abstract: | Diffuse tumor infiltration into the adjacent parenchyma is an effective dissemination mechanism of brain tumors. We have previously developed correlated high field magnetic resonance imaging and ultramicroscopy (MR-UM) to study neonangiogenesis in a glioma model. In the present study we used MR-UM to investigate tumor infiltration and neoangiogenesis in a translational approach. We compare infiltration and neoangiogenesis patterns in four brain tumor models and the human disease: whereas the U87MG glioma model resembles brain metastases with an encapsulated growth and extensive neoangiogenesis, S24 experimental gliomas mimic IDH wildtype glioblastomas, exhibiting infiltration into the adjacent parenchyma and along white matter tracts to the contralateral hemisphere. MR-UM resolves tumor infiltration and neoangiogenesis longitudinally based on the expression of fluorescent proteins, intravital dyes or endogenous contrasts. Our study demonstrates the huge morphological diversity of brain tumor models regarding their infiltrative and neoangiogenic capacities and further establishes MR-UM as a platform for translational neuroimaging. |
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| DOI: | doi:10.3389/fnins.2018.01004 |
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| URL: | Volltext: https://doi.org/10.3389/fnins.2018.01004 |
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| | Volltext: https://www.frontiersin.org/articles/10.3389/fnins.2018.01004/full |
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| | DOI: https://doi.org/10.3389/fnins.2018.01004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | brain clearing |
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| | brain tumor models |
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| | Glioblastoma |
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| | magnetic resonance microscopy |
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| | tumor invasion |
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| | ultramicroscopy |
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| K10plus-PPN: | 1665334207 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Correlated MRI and ultramicroscopy (MR-UM) of brain tumors reveals vast heterogeneity of tumor infiltration and neoangiogenesis in preclinical models and human disease / Breckwoldt, Michael O. [VerfasserIn]; 10 January 2019 (Online-Ressource)
