Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Ter-Karapetyan, Alvard [VerfasserIn]   i
 Triphan, Simon M. F. [VerfasserIn]   i
 Jobst, Bertram [VerfasserIn]   i
 Anjorin, Angela [VerfasserIn]   i
 Ley-Zaporozhan, Julia [VerfasserIn]   i
 Ley, Sebastian [VerfasserIn]   i
 Sedlaczek, Oliver [VerfasserIn]   i
 Biederer, Jürgen [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Wielpütz, Mark Oliver [VerfasserIn]   i
Titel:Towards quantitative perfusion MRI of the lung in COPD
Titelzusatz:the problem of short-term repeatability
Verf.angabe:Alvard Ter-Karapetyan, Simon M.F. Triphan, Bertram J. Jobst, Angela F. Anjorin, Julia Ley-Zaporozhan, Sebastian Ley, Oliver Sedlaczek, Jürgen Biederer, Hans-Ulrich Kauczor, Peter M. Jakob, Mark O. Wielpütz
E-Jahr:2018
Jahr: December 10, 2018
Umfang:12 S.
Fussnoten:Gesehen am 14.5.2019
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2018
Band/Heft Quelle:13(2018,12) Artikel-Nummer e0208587, 12 Seiten
ISSN Quelle:1932-6203
Abstract:Purpose 4D perfusion magnetic resonance imaging (MRI) with intravenous injection of contrast agent allows for a radiation-free assessment of regional lung function. It is therefore a valuable method to monitor response to treatment in patients with chronic obstructive pulmonary disease (COPD). This study was designed to evaluate its potential for monitoring short-term response to hyperoxia in COPD patients. Materials and methods 19 prospectively enrolled COPD patients (median age 66y) underwent paired dynamic contrast-enhanced 4D perfusion MRI within 35min, first breathing 100% oxygen (injection 1, O2) and then room air (injection 2, RA), which was repeated on two consecutive days (day 1 and 2). Post-processing software was employed to calculate mean transit time (MTT), pulmonary blood volume (PBV) and pulmonary blood flow (PBF), based on the indicator dilution theory, for the automatically segmented whole lung and 12 regions of equal volume. Results Comparing O2 with RA conditions, PBF and PBV were found to be significantly lower at O2, consistently on both days (p<10-8). Comparing day 2 to day 1, MTT was shorter by 0.59±0.63 s (p<10-8), PBF was higher by 22±80 ml/min/100ml (p<3·10-4), and PBV tended to be lower by 0.2±7.2 ml/100ml (p = 0.159) at both, RA and O2, conditions. Conclusion The second injection (RA) yielded higher PBF and PBV, which apparently contradicts the established hypothesis that hyperoxia increases lung perfusion. Quantification of 4D perfusion MRI by current software approaches may thus be limited by residual circulating contrast agent in the short-term and even the next day.
DOI:doi:10.1371/journal.pone.0208587
URL:Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0208587
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208587
 DOI: https://doi.org/10.1371/journal.pone.0208587
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amperometry
 Blood flow
 Blood volume
 Chronic obstructive pulmonary disease
 Hyperoxia
 Magnetic resonance imaging
 Pulmonary function
 Pulmonary imaging
K10plus-PPN:1665338261
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68389582   QR-Code
zum Seitenanfang