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Status: Bibliographieeintrag

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Verfasst von:Förster, Alex [VerfasserIn]   i
 Brehmer, Stefanie [VerfasserIn]   i
 Seiz-Rosenhagen, Marcel [VerfasserIn]   i
 Mildenberger, Iris [VerfasserIn]   i
 Giordano, Frank Anton [VerfasserIn]   i
 Wenz, Holger [VerfasserIn]   i
 Reuss, David [VerfasserIn]   i
 Hänggi, Daniel [VerfasserIn]   i
 Groden, Christoph [VerfasserIn]   i
Titel:Heterogeneity of glioblastoma with gliomatosis cerebri growth pattern on diffusion and perfusion MRI
Verf.angabe:Alex Förster, Stefanie Brehmer, Marcel Seiz-Rosenhagen, Iris Mildenberger, Frank A. Giordano, Holger Wenz, David Reuss, Daniel Hänggi, Christoph Groden
Jahr:2019
Jahr des Originals:2018
Umfang:7 S.
Fussnoten:Published online: 18 December 2018 ; Gesehen am 14.05.2019
Titel Quelle:Enthalten in: Journal of neuro-oncology
Ort Quelle:Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983
Jahr Quelle:2019
Band/Heft Quelle:142(2019), 1, Seite 103-109
ISSN Quelle:1573-7373
Abstract:Background and purposeGliomatosis cerebri (GC) is a rare growth pattern of glioblastoma whose diffuse nature is reflected by unspecific, relatively uniform findings on conventional MRI. In the present study we sought to evaluate the additional value of diffusion (DWI) and perfusion weighted (PWI) MRI for a more detailed characterization.MethodsWe analyzed the MRI findings in patients with histologically proven glioblastoma with GC growth pattern with a specific emphasis on T2 lesion pattern, volume, relative apparent diffusion coefficient (rACD), and relative cerebral blood volume (rCBV) and compared these to age-/gender-matched patients with localized glioblastoma.ResultsOverall, 16 patients (median age 59.5 years, 4 male) were included in the study. Of these, 8 patients had a glioblastoma with GC growth pattern, and 8 a classical localized growth pattern. While the median rADC (1.27 [IQR 1.12-1.41]) within the T2 lesion was significant lower in glioblastoma with GC growth pattern compared to localized glioblastoma (1.74 [IQR 1.45-1.96]; p = 0.003), the median T2 lesion volume and rCBV within the T2 lesion did not differ significantly. Furthermore, six patients with glioblastoma with GC growth pattern showed focal areas with significantly reduced rADC (p = 0.043), and/or increased rCBV (p = 0.028).ConclusionsLower rADC in glioblastoma with GC growth pattern might reflect the diffuse tumor cell infiltration whereas focal areas with decreased rADC and/or increased rCBV probably indicate high tumor cell density and/or abnormal tumor vessels which may be useful for biopsy guidance.
DOI:doi:10.1007/s11060-018-03068-w
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s11060-018-03068-w
 DOI: https://doi.org/10.1007/s11060-018-03068-w
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Diffusion-weighted imaging
 DWI
 Glioblastoma
 Gliomatosis cerebri
 Heterogeneity
 Perfusion-weighted imaging
 PWI
K10plus-PPN:1665347279
Verknüpfungen:→ Zeitschrift

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