A new bronchoscopic catheter for the transbronchial ablation of pulmonary nodules

• Verfasst von: Safi, Seyer [VerfasserIn]
• Verfasst von: Winkel, Jan op den [VerfasserIn]
• Verfasst von: Muley, Thomas [VerfasserIn]
• Verfasst von: Herth, Felix [VerfasserIn]
• Titel: A new bronchoscopic catheter for the transbronchial ablation of pulmonary nodules
• Verf.angabe: Seyer Safi, Jan op den Winkel, Steve Kramer, Thomas Keast, Henky Wibowo, Thomas Muley, Felix J.F. Herth
• E-Jahr: 2018
• Jahr: 26 July 2018
• Umfang: 5 S.
• Teil: volume:124
• Teil: year:2018
• Teil: pages:125-129
• Teil: extent:5
• Fussnoten: Gesehen am 14.05.2019
• Titel Quelle: Enthalten in: Lung cancer
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1985
• Jahr Quelle: 2018
• Band/Heft Quelle: 124(2018), Seite 125-129
• ISSN Quelle: 1872-8332
• DOI: doi:10.1016/j.lungcan.2018.07.038
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Bronchoscopy
• Sach-SW: Lung cancer
• Sach-SW: Pulmonary nodule
• Sach-SW: Radiofrequency ablation
• K10plus-PPN: 1665451270

Abstract

Objectives - With the objective of simultaneous bronchoscopic biopsy and ablation of malignant solitary pulmonary nodules, we have developed a flexible monopolar radiofrequency (RF) catheter that can be deployed through the working channel of most bronchoscopes. - Materials and Methods - Fresh tumor specimens were heated in a water bath to 37 °C, and the RF catheter was inserted into the tumors within the specimen. Temperature sensors were positioned 3 mm, 5 mm and 7 mm from the electrode to measure the temperature of the surrounding tissue every 1 s. The ablation was conducted by applying RF energy for 8 min. The ablated specimens were evaluated by cutting the tissue samples along the top of the device and measuring the ablation zones. - Results - Five ablations were performed in 3 specimens. All of the ablation zones had a major axis length (along the electrode axis) between 18.9 mm and 22.8 mm and a minor axis length (perpendicular to the major axis) between 13.3 mm and 18.0 mm. The temperature data showed that all of the temperature sensors detected 60 °C or higher. These results demonstrate that the RF catheter was capable of generating ablation zones that were locally contained in ex vivo human cancerous lung specimens and that incorporated the tumor tissues. - Conclusion - We present the results of a benchtop study demonstrating the local control of ablation achieved using the RF device. This study suggests that the ex vivo ablation of lung malignancy with a new bronchoscopic RF catheter is feasible and that in vivo tumor ablation with this method in humans merits further study.