| |  Online-Ressource |
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| Verfasst von: | Christopoulos, Petros [VerfasserIn]  |
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| | Endris, Volker [VerfasserIn] |
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| | Bozorgmehr, Farastuk [VerfasserIn] |
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| | El Sayed, Mei [VerfasserIn] |
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| | Kirchner, Martina [VerfasserIn] |
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| | Ristau, Jonas [VerfasserIn] |
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| | Buchhalter, Ivo [VerfasserIn] |
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| | Penzel, Roland [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Heußel, Claus Peter [VerfasserIn] |
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| | Eichhorn, Martin E. [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Meister, Michael [VerfasserIn] |
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| | Rieken, Stefan [VerfasserIn] |
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| | Warth, Arne [VerfasserIn] |
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| | Bischoff, Helge [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| | Stenzinger, Albrecht [VerfasserIn] |
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| | Thomas, Michael [VerfasserIn] |
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| Titel: | EML4-ALK fusion variant V3 is a high-risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK+ non-small cell lung cancer |
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| Verf.angabe: | Petros Christopoulos, Volker Endris, Farastuk Bozorgmehr, Mei Elsayed, Martina Kirchner, Jonas Ristau, Ivo Buchhalter, Roland Penzel, Felix J. Herth, Claus P. Heussel, Martin Eichhorn, Thomas Muley, Michael Meister, Jürgen R. Fischer, Stefan Rieken, Arne Warth, Helge Bischoff, Peter Schirmacher, Albrecht Stenzinger, Michael Thomas |
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| E-Jahr: | 2018 |
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| Jahr: | [15 June 2018] |
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| Umfang: | 10 S. |
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| Teil: | volume:142 |
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| | year:2018 |
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| | number:12 |
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| | pages:2589-2598 |
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| | extent:10 |
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| Fussnoten: | First published: 24 January 2018 ; Gesehen am 14.05.2019 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 142(2018), 12, Seite 2589-2598 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | In order to identify anaplastic lymphoma kinase-driven non-small cell lung cancer (ALK+ NSCLC) patients with a worse outcome, who might require alternative therapeutic approaches, we retrospectively analyzed all stage IV cases treated at our institutions with one of the main echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion variants V1, V2 and V3 as detected by next-generation sequencing or reverse transcription-polymerase chain reaction (n = 67). Progression under tyrosine kinase inhibitor (TKI) treatment was evaluated both according to Response Evaluation Criteria in Solid Tumors (RECIST) and by the need to change systemic therapy. EML4-ALK fusion variants V1, V2 and V3 were found in 39%, 10% and 51% of cases, respectively. Patients with V3-driven tumors had more metastatic sites at diagnosis than cases with the V1 and V2 variants (mean 3.3 vs. 1.9 and 1.6, p = 0.005), which suggests increased disease aggressiveness. Furthermore, V3-positive status was associated with earlier failure after treatment with first and second-generation ALK TKI (median progression-free survival [PFS] by RECIST in the first line 7.3 vs. 39.3 months, p = 0.01), platinum-based combination chemotherapy (median PFS 5.4 vs. 15.2 months for the first line, p = 0.008) and cerebral radiotherapy (median brain PFS 6.1 months vs. not reached for cerebral radiotherapy during first-line treatment, p = 0.028), and with inferior overall survival (39.8 vs. 59.6 months in median, p = 0.017). Thus, EML4-ALK fusion variant V3 is a high-risk feature for ALK+ NSCLC. Determination of V3 status should be considered as part of the initial workup for this entity in order to select patients for more aggressive surveillance and treatment strategies. |
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| DOI: | doi:10.1002/ijc.31275 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/ijc.31275 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31275 |
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| | DOI: https://doi.org/10.1002/ijc.31275 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ALK+ NSCLC |
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| | EML4-ALK fusion variant |
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| | metastasis |
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| | survival |
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| | treatment failure |
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| K10plus-PPN: | 1665454989 |
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| Verknüpfungen: | → Zeitschrift |
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EML4-ALK fusion variant V3 is a high-risk feature conferring accelerated metastatic spread, early treatment failure and worse overall survival in ALK+ non-small cell lung cancer / Christopoulos, Petros [VerfasserIn]; [15 June 2018] (Online-Ressource)
