Probing the endocannabinoid system in healthy volunteers

• Verfasst von: Grimm, Oliver [VerfasserIn]
• Verfasst von: Löffler, Martin [VerfasserIn]
• Verfasst von: Kamping, Sandra [VerfasserIn]
• Verfasst von: Leweke, F. Markus [VerfasserIn]
• Verfasst von: Flor, Herta [VerfasserIn]
• Titel: Probing the endocannabinoid system in healthy volunteers
• Titelzusatz: Cannabidiol alters fronto-striatal resting-state connectivity
• Verf.angabe: Oliver Grimm, Martin Löffler, Sandra Kamping, Aljoscha Hartmann, Cathrin Rohleder, Markus Leweke, Herta Flor
• E-Jahr: 2018
• Jahr: 7 June 2018
• Umfang: 9 S.
• Fussnoten: Gesehen am 15.05.2019
• Titel Quelle: Enthalten in: European neuropsychopharmacology
• Ort Quelle: Amsterdam : Elsevier, 1990
• Jahr Quelle: 2018
• Band/Heft Quelle: 28(2018), 7, Seite 841-849
• ISSN Quelle: 1873-7862
• DOI: doi:10.1016/j.euroneuro.2018.04.004
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cannabidiol
• Sach-SW: Frontal cortex
• Sach-SW: Functional connectivity
• Sach-SW: Resting state fMRI
• Sach-SW: Striatum
• Sach-SW: Tetrahydrocannabinol
• K10plus-PPN: 1665689404

Abstract

Tetrahydrocannabinol (THC) and Cannabidiol (CBD) are two substances from cannabis sativa that have beenimplicated in the treatment of mental and neurological disorders. We concentrated on a previously validated neuroimaging phenotype, fronto-striatal connectivity across different striatal seeds, because of this loop's relevance to executive functioning, decision making, salience generation and motivation and its link to various neuropsychiatric conditions. Therefore, we studied the effect of THC and CBD on fronto-striatal circuitry by a seed-voxel connectivity approach using seeds from the caudate and the putamen. We conducted a cross-over pharmaco-fMRI study in 16 healthy male volunteers with placebo, 10mg oral THC and 600mg oral CBD. Resting state was measured in a 3 T scanner. CBD lead to an increase of fronto-striatal connectivity in comparison to placebo. In contrast to our expectation that THC and CBD show opposing effects, THC versus placebo did not show any significant effects, probably due to insufficient concentration of THC during scanning. The effect of CBD on enhancing fronto-striatal connectivity is of interest because it might be a neural correlate of its anti-psychotic effect in patients.