Flow MR fingerprinting

• Verfasst von: Flassbeck, Sebastian [VerfasserIn]
• Verfasst von: Bachert, Peter [VerfasserIn]
• Verfasst von: Ladd, Mark E. [VerfasserIn]
• Titel: Flow MR fingerprinting
• Verf.angabe: Sebastian Flassbeck, Simon Schmidt, Peter Bachert, Mark E. Ladd, Sebastian Schmitter
• E-Jahr: 2019
• Jahr: [April 2019]
• Umfang: 15 S.
• Illustrationen: Illustrationen
• Fussnoten: First published: 02 December 2018 ; Gesehen am 16.05.2019
• Titel Quelle: Enthalten in: Magnetic resonance in medicine
• Ort Quelle: New York, NY [u.a.] : Wiley-Liss, 1984
• Jahr Quelle: 2019
• Band/Heft Quelle: 81(2019), 4, Seite 2536-2550
• ISSN Quelle: 1522-2594
• DOI: doi:10.1002/mrm.27588
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1665786418

Abstract

Purpose To investigate the feasibility to quantify blood velocities within the magnetic resonance fingerprinting framework, while providing relaxometric maps of static tissue. Methods Bipolar gradients are inserted into an SSFP-based MRF sequence to achieve velocity-dependent signal phases, allowing tri-directional time-resolved velocity component quantification. The accuracy of both relaxometric mapping and velocity quantification was validated in vivo and in phantom studies. Results Simulations determined that even for strong cardiac cycle length variations (700-1400 ms) Flow-MRF determines accurate velocity maps deviating <0.1% from the ground truth on average. The cardiac cycle length variability only results in reduced velocity-to-noise ratios. Good agreement in the velocity quantification between a standard phase-contrast cine and the Flow-MRF sequence was reached in phantom experiments. Relaxometric phantom experiments determined mean deviations between Flow-MRF and spin-echo-based reference measurements of 89 ± 25 ms / 0.8 ± 2.5 ms over the range of 630-2630 ms / 49-145 ms for T1 / T2, respectively. The in vivo study of a human knee determined mean T1 / T2 values of 1383 ± 75 ms / 26 ± 4 ms for the gastrocnemius muscle that agree with literature values. Conclusion Flow-MRF presents a novel way of quantifying velocities while simultaneously providing relaxometric maps of static tissue and it can potentially be a viable method to accelerate the inherently long acquisition times of time-resolved velocity quantification.