Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Sandner, Beatrice [VerfasserIn]   i
 Puttagunta, Radhika [VerfasserIn]   i
 Motsch, Melanie [VerfasserIn]   i
 Blesch, Armin [VerfasserIn]   i
 Weidner, Norbert [VerfasserIn]   i
Titel:Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats
Verf.angabe:Beatrice Sandner, Radhika Puttagunta, Melanie Motsch, Frank Bradke, Jörg Ruschel, Armin Blesch, Norbert Weidner
E-Jahr:2018
Jahr:02 February 2018
Umfang:10 S.
Fussnoten:Gesehen am 17.05.2019
Titel Quelle:Enthalten in: Experimental neurology
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1959
Jahr Quelle:2018
Band/Heft Quelle:306(2018), Seite 250-259
ISSN Quelle:1090-2430
Abstract:Following a spinal cord injury (SCI) a growth aversive environment forms, consisting of a fibroglial scar and inhibitory factors, further restricting the already low intrinsic growth potential of injured adult central nervous system (CNS) neurons. Previous studies have shown that local administration of the microtubule-stabilizing drug paclitaxel or epothilone B (Epo B) reduce fibrotic scar formation and axonal dieback as well as induce axonal growth/sprouting after SCI. Likewise, systemic administration of Epo B promoted functional recovery. In this study, we investigated the effects of epothilone D (Epo D), an analog of Epo B with a possible greater therapeutic index, on fibrotic scarring, axonal sprouting and functional recovery after SCI. Delayed systemic administration of Epo D after a moderate contusion injury (150kDyn) in female Fischer 344 rats resulted in a reduced number of footfalls when crossing a horizontal ladder at 4 and 8weeks post-injury. Hindlimb motor function assessed with the BBB open field locomotor rating scale and Catwalk gait analysis were not significantly altered. Moreover, formation of laminin positive fibrotic scar tissue and 5-HT positive serotonergic fiber length caudal to the lesion site were not altered after treatment with Epo D. These findings recapitulate a functional benefit after systemic administration of a microtubule-stabilizing drug in rat contusion SCI.
DOI:doi:10.1016/j.expneurol.2018.01.018
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.expneurol.2018.01.018
 Volltext: http://www.sciencedirect.com/science/article/pii/S0014488618300311
 DOI: https://doi.org/10.1016/j.expneurol.2018.01.018
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Epothilone D
 Functional recovery
 Microtubule stability
 Moderate contusion
 Spinal cord injury
K10plus-PPN:1665887443
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68390735   QR-Code
zum Seitenanfang