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Verfasst von:Winkelmann, Tobias [VerfasserIn]   i
 Ruttorf, Michaela [VerfasserIn]   i
 Schad, Lothar R. [VerfasserIn]   i
 Flor, Herta [VerfasserIn]   i
Titel:Brain morphology correlates of interindividual differences in conditioned fear acquisition and extinction learning
Verf.angabe:Tobias Winkelmann, Oliver Grimm, Sebastian T. Pohlack, Frauke Nees, Raffaele Cacciaglia, Ramona Dinu-Biringer, Frauke Steiger, Manon Wicking, Michaela Ruttorf, Lothar R. Schad, Herta Flor
Jahr:2016
Jahr des Originals:2015
Umfang:11 S.
Fussnoten:Gesehen am 21.05.2019 ; Published online: 26 February 2015
Titel Quelle:Enthalten in: Brain structure & function
Ort Quelle:Berlin : Springer, 2007
Jahr Quelle:2016
Band/Heft Quelle:221(2016), 4, Seite 1927-1937
ISSN Quelle:1863-2661
Abstract:The neural circuits underlying fear learning have been intensively investigated in pavlovian fear conditioning paradigms across species. These studies established a predominant role for the amygdala in fear acquisition, while the ventromedial prefrontal cortex (vmPFC) has been shown to be important in the extinction of conditioned fear. However, studies on morphological correlates of fear learning could not consistently confirm an association with these structures. The objective of the present study was to investigate if interindividual differences in morphology of the amygdala and the vmPFC are related to differences in fear acquisition and extinction learning in humans. We performed structural magnetic resonance imaging in 68 healthy participants who underwent a differential cued fear conditioning paradigm. Volumes of subcortical structures as well as cortical thickness were computed by the semi-automated segmentation software Freesurfer. Stronger acquisition of fear as indexed by skin conductance responses was associated with larger right amygdala volume, while the degree of extinction learning was positively correlated with cortical thickness of the right vmPFC. Both findings could be conceptually replicated in an independent sample of 53 subjects. The data complement our understanding of the role of human brain morphology in the mechanisms of the acquisition and extinction of conditioned fear.
DOI:doi:10.1007/s00429-015-1013-z
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00429-015-1013-z
 Volltext: https://link.springer.com/article/10.1007%2Fs00429-015-1013-z
 DOI: https://doi.org/10.1007/s00429-015-1013-z
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amygdala
 Brain structure
 Cortical thickness
 Extinction learning
 Fear conditioning
 vmPFC
K10plus-PPN:1666037680
Verknüpfungen:→ Zeitschrift

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