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Verfasst von:Grützner, Thea M. [VerfasserIn]   i
 Sharma, Anuradha [VerfasserIn]   i
 Bartolovic, Marina [VerfasserIn]   i
 Weisbrod, Matthias [VerfasserIn]   i
 Roesch-Ely, Daniela [VerfasserIn]   i
Titel:Neurocognitive performance in patients with depression compared to healthy controls
Titelzusatz:Association of clinical variables and remission state
Verf.angabe:Thea Marianne Grützner, Anuradha Sharma, Lena Listunova, Marina Bartolovic, Matthias Weisbrod, Daniela Roesch-Ely
Jahr:2019
Umfang:8 S.
Fussnoten:Available online 20 November 2018 ; Gesehen am 23.05.2019
Titel Quelle:Enthalten in: Psychiatry research
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1979
Jahr Quelle:2019
Band/Heft Quelle:271(2019), Seite 343-350
ISSN Quelle:1872-7123
Abstract:Cognitive impairment in Major Depressive Disorder (MDD) has been postulated to persist into remission. However, inconsistent definitions of clinical remission, patterns and influencing factors, isolated cognitive tasks, and the lack of appropriately matched controls (HCs) present significant limitations of previous studies. Furthermore, studies investigating cognition in partially remitted patients are particularly scarce. This study compares the cognition of MDD patients (N=65) and HCs (N=65), matched by one-to-one recruitment strategy for age, sex, and education (ages 19-60). The neuropsychological (NPS) performance was measured via an extensive NPS-test battery and analysed retrospectively, accounting for demographic and clinical variables. Full remission was defined as HAMD cut off ≤7, partial remission as HAMD 8-18. The findings show entire MDD group and partially remitted MDD with significantly poorer NPS performance compared to HCs, while remitted MDD patients did not differ significantly from HCs. This underscores how critical a clear definition of remission is to compare studies on MDD. The clinical variable ‘number of hospitalizations’ had a significant effect on cognition, whereas current symptom severity did not correlate with performance on any cognitive domain. Higher number of hospitalizations may be associated with higher burden of illness and greater neurobiological “scar effects”.
DOI:doi:10.1016/j.psychres.2018.11.047
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.psychres.2018.11.047
 Volltext: http://www.sciencedirect.com/science/article/pii/S0165178118305031
 DOI: https://doi.org/10.1016/j.psychres.2018.11.047
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cognitive impairment
 Hospitalization
 Major depressive disorder
 Neuropsychological performance
K10plus-PPN:1666184551
Verknüpfungen:→ Zeitschrift

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