Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer

• Verfasst von: Himbert, Caroline [VerfasserIn]
• Verfasst von: Ose, Jennifer [VerfasserIn]
• Verfasst von: Nattenmüller, Johanna [VerfasserIn]
• Verfasst von: Warby, Christy A. [VerfasserIn]
• Verfasst von: Holowatyi, Andreana N. [VerfasserIn]
• Verfasst von: Böhm, Jürgen [VerfasserIn]
• Verfasst von: Lin, Tengda [VerfasserIn]
• Verfasst von: Haffa, Mariam [VerfasserIn]
• Verfasst von: Gigić, Biljana [VerfasserIn]
• Verfasst von: Hardikar, Sheetal [VerfasserIn]
• Verfasst von: Scherer, Dominique [VerfasserIn]
• Verfasst von: Zielske, Lin [VerfasserIn]
• Verfasst von: Schrotz-King, Petra [VerfasserIn]
• Verfasst von: Kölsch, Torsten [VerfasserIn]
• Verfasst von: Siegel, Erin M. [VerfasserIn]
• Verfasst von: Shibata, David [VerfasserIn]
• Verfasst von: Ulrich, Alexis [VerfasserIn]
• Verfasst von: Schneider, Martin [VerfasserIn]
• Verfasst von: Hursting, Stephen D. [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Ulrich, Cornelia [VerfasserIn]
• Titel: Body fatness, adipose tissue compartments, and biomarkers of inflammation and angiogenesis in colorectal cancer
• Titelzusatz: the ColoCare Study
• Verf.angabe: Caroline Himbert, Jennifer Ose, Johanna Nattenmüller, Christy A. Warby, Andreana N. Holowatyj, Jürgen Böhm, Tengda Lin, Mariam Haffa, Biljana Gigic, Sheetal Hardikar, Dominique Scherer, Lin Zielske, Petra Schrotz-King, Torsten Kölsch, Erin M. Siegel, David Shibata, Alexis Ulrich, Martin Schneider, Stephen D. Hursting, Hans-Ulrich Kauczor, and Cornelia M. Ulrich
• E-Jahr: 2019
• Jahr: January 2019
• Umfang: 7 S.
• Fussnoten: Gesehen am 24.05.2019
• Titel Quelle: Enthalten in: Cancer epidemiology, biomarkers & prevention
• Ort Quelle: Philadelphia, Pa. : AACR, 1991
• Jahr Quelle: 2019
• Band/Heft Quelle: 28(2019), 1, Seite 76-82
• ISSN Quelle: 1538-7755
• DOI: doi:10.1158/1055-9965.EPI-18-0654
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1666255947

Abstract

Background: Adiposity has been linked to both risk and prognosis of colorectal cancer; however, the impact of different fat areas [visceral (VFA) vs. subcutaneous fat area (SFA)] is unclear. We investigated associations between adiposity and biomarkers of inflammation and angiogenesis among patients with colorectal cancer. - Methods: Preoperative serum samples and computed tomography scans were obtained from 188 patients diagnosed with primary invasive stage I-IV colorectal cancer enrolled in the ColoCare Study. Adiposity was assessed by area-based quantification of VFA, SFA, and VFA:SFA ratio on spinal levels L3/L4 and L4/L5. Circulating levels of inflammation (CRP, SAA, sICAM-1, and sVCAM-1) and angiogenesis (VEGF-A and VEGF-D) were assessed from patient sera on the Meso Scale Discovery platform. Partial correlations and regression analyses, adjusted for age, sex, and tumor stage, were performed. - Results: VFA was moderately correlated with CRP and SAA (CRP: L3/L4 and L4/L5:r = 0.21, P = 0.01; SAA: L3/L4:r = 0.17, P = 0.04). The correlation between SFA and the measured biomarkers were weak (r ≤ 0.13, not significant). The ratio of VFA:SFA at L3/L4 was moderately correlated with VEGF-A (r = 0.28, P = 0.0008) and SAA (r = 0.24, P = 0.006), and less so with CRP (r = 0.18, P = 0.04) and sICAM-1 (r = 0.18, P = 0.04). Similar correlations were found for the VFA:SFA ratio at L4/L5. - Conclusions: We observed an association between visceral adiposity and biomarkers of inflammation and angiogenesis in colorectal cancer. In particular, the VFA:SFA ratio was correlated with circulating levels of the proangiogenic biomarker VEGF-A. - Impact: Our findings support a direct association of visceral adipose tissue with inflammatory and angiogenic processes, which play fundamental roles in the development and progression of colorectal cancer.